Showing papers by "Lina Bezdetnaya published in 2005"
TL;DR: Compared to albumin, Foscan disaggregation kinetics in the presence of lipoproteins displayed poorer dependency on lipoprotein concentrations and smaller variations in disaggregation rate constants.
80 citations
TL;DR: The observation of the fluence rate-dependent modulation of caspase-3 activity in spheroids offers the possibility of regulating the mechanism of direct cell photodamage and could be of great potential in the clinical context.
78 citations
TL;DR: The feasibility of endoscopic, in vivo, fiber-optic confocal microscopy in the rat bladder is reported and tumors from normal epithelium are distinguished and the different epithelial cell types in nontransformed rat bladder epithelia are visualized.
50 citations
TL;DR: Spectroscopic measurements evidenced photomodification as the main process after m-THPP irradiation and new photoproducts were attributed to covalent oligomeric structures as dimer, trimer, tetramer and pentamer of m- THPP.
Abstract: This study examined the nature of photoproducts after pulse laser irradiation (647.5 nm) of 5,10,15,20-tetrakis(meso-hydroxyphenyl)porphyrin (m-THPP) (10 μmol/L) in ethanol-water (1/99, vol/vol) solution. Spectroscopic measurements (UV-visible absorption and fluorescence) and mass spectrometry techniques (matrix-assisted laser desorption-ionization [MALDI] coupled with time-of-flight mass spectrometer [TOF-MS] or tandem time of flight mass spectrometer [TOF/TOF-MS]) were used to follow photomodifications. Spectroscopic measurements evidenced photomodification as the main process after m-THPP irradiation. Three oxidized photoproducts at m/z 693.25, 695.24 and 713.25 were characterized by MS. After prolonged irradiation new isotopic distributions were registered at m/z 1355.41, 2031.57, 2707.80 and 3383.98 with MALDI-TOF-MS and TOF/TOF-MS. These new photoproducts were attributed to covalent oligomeric structures as dimer, trimer, tetramer and pentamer of m-THPP.
4 citations