L
Lindsey M. Williams
Researcher at Veterans Health Administration
Publications - 4
Citations - 280
Lindsey M. Williams is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Blood–brain barrier & Biology. The author has an hindex of 2, co-authored 2 publications receiving 88 citations.
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Journal ArticleDOI
The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.
Elizabeth M. Rhea,Aric F. Logsdon,Aric F. Logsdon,Kim M. Hansen,Kim M. Hansen,Lindsey M. Williams,May J. Reed,Kristen K. Baumann,Sarah Holden,Jacob Raber,William A. Banks,William A. Banks,Michelle A. Erickson +12 more
TL;DR: It is shown that intravenously injected radioiodinated S1 readily crossed the blood-brain barrier (BBB) in male mice, was taken up by brain regions and entered the parenchymal brain space, and I-S1 uptake in the hippocampus and olfactory bulb was reduced by lipopolysaccharide-induced inflammation.
Posted ContentDOI
The S1 protein of SARS-CoV-2 crosses the blood-brain barrier: Kinetics, distribution, mechanisms, and influence of ApoE genotype, sex, and inflammation
Elizabeth M. Rhea,Elizabeth M. Rhea,Aric F. Logsdon,Aric F. Logsdon,Kim M. Hansen,Lindsey M. Williams,May J. Reed,May J. Reed,Kristen K. Baumann,Sarah Holden,Jacob Raber,William A. Banks,William A. Banks,Michelle A. Erickson,Michelle A. Erickson +14 more
TL;DR: It is found that radioiodinated S1 (I-S1) readily crosses the murine blood-brain barrier (BBB), entering all brain regions and the peripheral tissues studied, likely by the mechanism of adsorptive transcytosis.
Journal ArticleDOI
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu
Lindsey M. Williams,Takashi Fujimoto,Riley R Weaver,Aric F. Logsdon,Kira Evitts,Jessica E. Young,William A. Banks,Michelle A. Erickson +7 more
TL;DR: In this paper , the authors characterized iBEC proliferative state in relation to key human blood-brain barrier (BBB) properties at early (2 days) and late (9 days) post-subculture time points.
Journal ArticleDOI
Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation
Daniel Quaranta,Riley R Weaver,Kristen K. Baumann,Takashi Fujimoto,Lindsey M. Williams,Hyung-Chan Kim,Aric F. Logsdon,Mohamed Omer,May J. Reed,William A. Banks,Michelle A. Erickson +10 more
TL;DR: In this article , the authors showed that 125I-labeled CCL2 and CCL5 crossed the intact blood-brain barrier (BBB) and entered the brain parenchyma.