L
Ling Huang
Researcher at Sun Yat-sen University
Publications - 81
Citations - 2856
Ling Huang is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Medicine & Acetylcholinesterase. The author has an hindex of 31, co-authored 67 publications receiving 2335 citations. Previous affiliations of Ling Huang include Hainan University.
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Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease
TL;DR: Compounds 5d and 10d are potential lead compounds for AD therapy and are capable of disassembling the highly structured Aβ fibrils generated by self- and Cu(II)-induced Aβ aggregation.
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Synthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer's Disease Based on the Fusion of Donepezil and Ebselen
Zonghua Luo,Jianfei Sheng,Yang Sun,Chuanjun Lu,Jun Yan,Anqiu Liu,Hai-Bin Luo,Ling Huang,Xingshu Li +8 more
TL;DR: A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and the antioxidant ebselen were designed as multi-target-directed ligands against Alzheimer's disease, and compound 7d, one of the most potent acetylcholinestersterase inhibitors, is able to penetrate the central nervous system.
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Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease
Ling Huang,Chuanjun Lu,Yang Sun,Fei Mao,Zonghua Luo,Tao Su,Huailei Jiang,Wenjun Shan,Xingshu Li +8 more
TL;DR: Results indicated that compound 41 is an excellent multifunctional agent for the treatment of AD.
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Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo.
TL;DR: 14k and its phosphate salt 14k-P inhibited tumor growth in xenograft models in vivo without apparent toxicity, which was better than the reference compound CA-4P and 2.7-fold increase in activity when compare with compound 2.8-8.7 nM.
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Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents
TL;DR: Mechanistic studies revealed that 11a is a potent tubulin polymerization inhibitor, which could arrest cell cycle at G2/M phase and induce apoptosis along with the decrease of mitochondrial membrane potential.