L
Ling Sing K. Chen
Publications - 4
Citations - 942
Ling Sing K. Chen is an academic researcher. The author has contributed to research in topics: Long QT syndrome & hERG. The author has an hindex of 2, co-authored 3 publications receiving 916 citations.
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Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate : implications for gene-specific therapy
Peter J. Schwartz,Silvia G. Priori,Emanuela H. Locati,Carlo Napolitano,Francesco Cantù,Jeffrey A. Towbin,Mark T. Keating,Hicham Hammoude,Arthur M. Brown,Ling Sing K. Chen,Thomas J. Colatsky +10 more
TL;DR: This is the first study to demonstrate differential responses of LQTS patients to interventions targeted to their specific genetic defect, and it is suggested that LQT3 patients may be more likely to benefit from Na+ channel blockers and from cardiac pacing because they would be at higher risk of arrhythmia at slow heart rates.
Journal Article
Erratum: Long QT syndrome patients with mutations on the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate: Implications for gene-specific therapy (Circulation (1995) 92 (3381-3386))
Peter J. Schwartz,S. G. Priori,Emanuela H. Locati,Carlo Napolitano,Francesco Cantù,J.A. Towbin,M T Keating,Hicham Hammoude,Arthur M. Brown,Ling Sing K. Chen,Thomas J. Colatsky +10 more
Journal ArticleDOI
Long QT syndrome patients genetically linked to defective genes on chromosomes 11, 7 and 3 present differential response to changes in heart rate
Silvia G. Priori,Carlo Napolitano,Emanuela H. Locati,Francesco Cantù,Marco Stramba-Badiale,Mark T. Keating,Jeffrey A. Towbin,Thomas J. Colatsky,Ling Sing K. Chen,Peter J. Schwartz +9 more
Journal ArticleDOI
Emerging roles of i-motif in gene expression and disease treatment
Xiaoqing Luo,Jiany Zhang,Yue Hua Gao,W. Pan,Yayuan Yang,Xu Li,Ling Sing K. Chen,Chang Wang,Yuqing Wang +8 more
TL;DR: In this paper , the characteristics and mechanisms of i-motifs located in gene promoters (including c-myc, Bcl-2, VEGF, and telomeres) were reviewed.