L
Ling-Wei Hsin
Researcher at National Taiwan University
Publications - 38
Citations - 745
Ling-Wei Hsin is an academic researcher from National Taiwan University. The author has contributed to research in topics: Receptor & Isoquinoline. The author has an hindex of 15, co-authored 35 publications receiving 679 citations. Previous affiliations of Ling-Wei Hsin include National Institutes of Health.
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Quinazolin-4-one Derivatives as Selective Histone Deacetylase-6 Inhibitors for the Treatment of Alzheimer’s Disease
TL;DR: In vitro, novel quinazolin-4-one derivatives containing a hydroxamic acid moiety induced neurite outgrowth accompanied by growth-associated protein 43 expression, and they enhanced the synaptic activities of PC12 and SH-SY5Y neuronal cells without producing toxic or mitogenic effects.
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The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats
TL;DR: These data suggest that reducing stress-induced increases in HPA activity alone may not be sufficient to produce antidepressant-like activity; however, reductions in H PA activity may contribute to antidepressant actions of some treatments.
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Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.
Ling-Wei Hsin,Christina M. Dersch,Michael H. Baumann,David Stafford,John R. Glowa,Richard B. Rothman,and Arthur E. Jacobson,Kenner C. Rice +7 more
TL;DR: 6 showed greater potency than 7 in elevating extracellular dopamine levels in a microdialysis assay and in inhibiting cocaine-maintained responding in rhesus monkeys, and the latter is one of the most DAT selective ligands known.
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Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.
David B. Lewis,Dorota Matecka,Ying Zhang,Ling-Wei Hsin,Christina M. Dersch,David Stafford,John R. Glowa,Richard B. Rothman,Kenner C. Rice +8 more
TL;DR: The identification of analogues 32, 34, and 36 provides three potential candidates for esterification and formulation as extended-release cocaine-abuse therapeutic agents.
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High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma.
TL;DR: It is demonstrated that J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma, and can be considered a potential therapeutic for the treatment of gliOBlastoma and other cancers.