Pei-Teh Chang

TL;DR: In vitro, novel quinazolin-4-one derivatives containing a hydroxamic acid moiety induced neurite outgrowth accompanied by growth-associated protein 43 expression, and they enhanced the synaptic activities of PC12 and SH-SY5Y neuronal cells without producing toxic or mitogenic effects.

TL;DR: This study demonstrates the significance of dual Aurora B/FLT3 inhibitors for the development of potential agents to treat AML by finding that compound 54 is more potent than sunitinib not only against FLT3-WT AML cells but also active against sunit inib-resistant FLT 3-ITD AML Cells.

TL;DR: In A549 cells, 31h decreased phosphorylation of histone H3, triggered polyploidy, induced expression of pro-apoptotic Fas and FasL with subsequent activation of caspase 8, resulting into apoptosis, and 4-Oxo-1,4-dihydropyridine derivatives demonstrated potent in vivo efficacy with a daily dose of 5 mg/kg.

TL;DR: Intraperitoneal administration of 30c at 100mg/kg demonstrated potent acute anti-inflammatory activity and benzo[1.3.2]dithiazolium ylide 1,1-dioxide represented a novel scaffold for the exploitation in developing dual COX-2/5-LOX inhibitors.

TL;DR: Results show that the effectiveness of J2326 on fAβ-driven neurodegeneration is ascribed to its novel scaffold, which might give clues to evolving attractive therapy for future clinical trials.