L
Linghong Huang
Researcher at University of Sheffield
Publications - 20
Citations - 541
Linghong Huang is an academic researcher from University of Sheffield. The author has contributed to research in topics: Tissue transglutaminase & Medicine. The author has an hindex of 10, co-authored 13 publications receiving 458 citations. Previous affiliations of Linghong Huang include Northern General Hospital.
Papers
More filters
Journal ArticleDOI
Transglutaminase inhibition ameliorates experimental diabetic nephropathy
Linghong Huang,John L. Haylor,Zoe Hau,Richard A. Jones,Melissa E. Vickers,Bart E. Wagner,Martin Griffin,Robert E. Saint,Ian G. C. Coutts,A. Meguid El Nahas,Timothy S. Johnson +10 more
TL;DR: It is suggested that transglutaminase inhibition ameliorates the progression of experimental diabetic nephropathy and can be considered for clinical application.
Journal ArticleDOI
Inhibition of Transglutaminase Activity Reduces Extracellular Matrix Accumulation Induced by High Glucose Levels in Proximal Tubular Epithelial Cells
Nicholas J. Skill,Nicholas J. Skill,Timothy S. Johnson,Ian G. C. Coutts,Robert E. Saint,Marie Fisher,Linghong Huang,A. Meguid El Nahas,Russell Collighan,Martin Griffin +9 more
TL;DR: Tg inhibition reduces glucose-induced deposition of ECM proteins independently of changes in ECM and transforming growth factor β1 synthesis thus opening up its possible application in the treatment other fibrotic and scarring diseases where tTg has been implicated.
Journal ArticleDOI
Development of a chronic kidney disease model in C57BL/6 mice with relevance to human pathology.
Linghong Huang,Alessandra Scarpellini,Muriel Funck,Elisabetta A.M. Verderio,Timothy S. Johnson +4 more
TL;DR: AAN can be induced in C57BL/6 mice with substantial tubulointerstitial fibrosis with lesions similar to those in humans.
Journal ArticleDOI
Syndecan-4 Knockout Leads to Reduced Extracellular Transglutaminase-2 and Protects against Tubulointerstitial Fibrosis
Alessandra Scarpellini,Linghong Huang,Izhar Burhan,Nina Schroeder,Muriel Funck,Timothy S. Johnson,Elisabetta A.M. Verderio +6 more
TL;DR: The lack of Sdc4 heparan sulfate chains in the kidneys of SDC4-null mice abrogates injury-induced externalization of TG2, thereby preventing profibrotic crosslinking of extracellular matrix and recruitment of large latent TGF-β1.
Journal ArticleDOI
Modulation of tissue transglutaminase in tubular epithelial cells alters extracellular matrix levels: a potential mechanism of tissue scarring.
Marie Fisher,Richard A. Jones,Linghong Huang,John L. Haylor,Meguid El Nahas,Martin Griffin,Timothy S. Johnson +6 more
TL;DR: It is reported that TG2 contributes to ECM accumulation primarily by accelerating collagen deposition, but also by altering the susceptibility of the tubular ECM to decay, support a role for TG2 in the expansion of the ECM associated with kidney scarring.