L
Lingyun Wu
Researcher at Shanghai Jiao Tong University
Publications - 88
Citations - 1446
Lingyun Wu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Decitabine & Myelodysplastic syndromes. The author has an hindex of 19, co-authored 75 publications receiving 1034 citations. Previous affiliations of Lingyun Wu include University of Nebraska Medical Center & Cincinnati Children's Hospital Medical Center.
Papers
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Journal ArticleDOI
Tumor-Associated Neutrophils in Cancer: Going Pro.
TL;DR: This review summarizes the most recent updates regarding neutrophil recruitments and functions in the tumor microenvironment as well as potential development of neutrophils-targeted putative therapeutic strategies.
Journal ArticleDOI
Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring.
Feng Xu,Xiao Li,Lingyun Wu,Qingxia Zhang,Rui Yang,Yujuan Yang,Zheng Zhang,Qi He,Chunkang Chang +8 more
TL;DR: Excessive overexpression of the EZH2, RING1, and BMI1 genes is common in MDS and indicate poor prognosis, as well as the relationship between the expression of PcG genes and epigenetic alteration and prognosis-risk scoring, which is explored for the first time.
Journal ArticleDOI
Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway.
Qingqing Zheng,Youshan Zhao,Juan Guo,Sida Zhao,Chengming Fei,Chao Xiao,Dong Wu,Lingyun Wu,Xiao Li,Chunkang Chang +9 more
TL;DR: The iron chelation or antioxidant weakened the activity of the AMPK/MFF/Drp1 pathway in MDS-MSCs with IO from several patients, accompanied by attenuation of mitochondrial fragmentation and autophagy.
Journal ArticleDOI
TP53 mutations predict decitabine-induced complete responses in patients with myelodysplastic syndromes.
Chunkang Chang,Youshan Zhao,Feng Xu,Juan Guo,Zheng Zhang,Qi He,Dong Wu,Lingyun Wu,Jiying Su,Lu-Xi Song,Chao Xiao,Xiao Li +11 more
TL;DR: TP53 mutations might predict decitabine‐induced complete responses in patients with MDS, and DAC‐induced responses may result from partial suppression of malignant clones containing mutated TP53 genes.
Book ChapterDOI
Neutrophils in the Tumor Microenvironment.
TL;DR: This chapter will discuss the phenotypic and functional changes in the neutrophil in the tumor microenvironment, the underlying mechanism(s) of neutrophic facilitated cancer metastasis, and clinical potential of neutrophils as a prognostic/diagnostic marker and therapeutic target.