L
Linsey E. Haswell
Researcher at Southampton General Hospital
Publications - 8
Citations - 906
Linsey E. Haswell is an academic researcher from Southampton General Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 3 publications receiving 878 citations. Previous affiliations of Linsey E. Haswell include University of Southampton.
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Journal ArticleDOI
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
Sandra S. Diebold,Maria Montoya,Hermann Unger,Lena Alexopoulou,Polly Roy,Linsey E. Haswell,Aymen Al-Shamkhani,Richard A. Flavell,Persephone Borrow,Caetano Reis e Sousa +9 more
TL;DR: The results suggest that multiple dendritic cell types, not just plasmacytoid cells, can act as specialized interferon-producing cells in certain viral infections, and reveal the existence of a TLR-independent pathway for d endritic cell activation that can be the target of viral interference.
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Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses.
Vadim Y. Taraban,Tania F. Rowley,Lyn O'Brien,H.T. Claude Chan,Linsey E. Haswell,Michael H. A. Green,Alison L. Tutt,Martin J. Glennie,Aymen Al-Shamkhani,Aymen Al-Shamkhani +9 more
TL;DR: stimulation of CD137 in vivo is considerably more effective than CD134 in augmenting anti‐tumor immune responses, and agents that stimulate signaling via CD137 are likely to be more useful in clinical conditions where highly effective CD8+ CTL responses are required.
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Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154
TL;DR: The construction of a novel soluble dodecameric form of CD154 (CD40 ligand) that is more effective than trimeric tCD154 in triggering B cell activation and directly regulates signaling by CD40 is described.
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Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance
Holger Behrsing,Adam Wahab,L. Ukishima,C. Grodi,Stefan Frentzel,Stephanie Johne,Shinkichi Ishikawa,Shigeaki Ito,Roman Wieczorek,Jessica Budde,Brian M Keyser,Linsey E. Haswell,David Thorne,Emma Bishop,Damien Breheny,Xuefei Cao,Qin Qin,Vivek Patel +17 more
TL;DR: Findings support the development and validation of a standardised CBF measurement protocol and make recommendations for researchers in the absence of a validated method.
Journal ArticleDOI
Application of ToxTracker for the toxicological assessment of tobacco and nicotine delivery products.
D. Smart,S. Bozhilova,Fabio Miazzi,Linsey E. Haswell,Marianna D. A. Gaça,David Thorne,Damien Breheny +6 more
TL;DR: In this paper , the authors used the validated technology ToxTracker® to assess biomarkers of DNA damage, protein misfolding, oxidative and cellular stress, across the categories of cigarette (1R6F), tobacco heating product (THP 1.4) and electronic cigarette (ePen 3).