L
Linus Sandegren
Researcher at Uppsala University
Publications - 54
Citations - 4004
Linus Sandegren is an academic researcher from Uppsala University. The author has contributed to research in topics: Antibiotic resistance & Plasmid. The author has an hindex of 26, co-authored 44 publications receiving 3238 citations. Previous affiliations of Linus Sandegren include Stockholm University.
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Transfer of an Escherichia coli ST131 multiresistance cassette has created a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial outbreak
TL;DR: The complete sequence, horizontal spread and stability of the CTX-M-15-encoding multiresistance plasmid of a Klebsiella pneumoniae strain involved in a large nosocomial outbreak is characterized and confers a fitness cost when introduced into a naive host cell.
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The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15.
TL;DR: The outbreak of multidrug‐resistant isolates of Klebsiella pneumoniae in Scandinavia demonstrates the epidemic potential of enterobacteria containing ESBLs of the CTX‐M type, even in a country with a relatively low selective pressure and a low prevalence of multiresistant bacteria.
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Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance
TL;DR: It is predicted that Tet(X) might become the most problematic future Tet determinant, since its weak intrinsic tigecycline activity can be mutationally improved to reach clinically relevant levels without collateral loss in activity to other tetracyclines.
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Antimicrobial drug-resistant Escherichia coli in wild birds and free-range poultry, Bangladesh.
Badrul Hasan,Linus Sandegren,Åsa Melhus,Mirva Drobni,Jorge A. Hernandez,Jonas Waldenström,Munirul Alam,Bjorn R. Olsen +7 more
TL;DR: Multidrug resistance was found in 22.7% of Escherichia coli isolates from bird samples in Bangladesh; 30% produced extended-spectrum β-lactamases, including clones of CTX-M genes among wild and domestic birds.
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High Fitness Costs and Instability of Gene Duplications Reduce Rates of Evolution of New Genes by Duplication-Divergence Mechanisms
TL;DR: The experimental results show that the costs of carrying extra gene copies are substantial and that each additional kilo base pairs of DNA reduces fitness by approximately 0.15%, but that these effects can be offset by positive selection for novel beneficial functions.