Copper-Catalyzed Intermolecular Trifluoromethylthiocyanation of Alkenes: Convenient Access to CF3-Containing Alkyl Thiocyanates

Enantioselective Organocatalyzed Direct α-Thiocyanation of Cyclic β-Ketoesters by N-Thiocyanatophthalimide

An efficient and highly selective approach for intermolecular arylthiocyanation/arylselenocyanation of alkenes has been reported under mild conditions. Using diazonium salts as the arylating agent and ammonium thiocyanate as the thiocyanate source, chemoselective difunctionalization of alkenes has been done under irradiation of visible light. Both styrenes and acrylates work well to deliver various aryl-substituted alkylthiocyanates in good to excellent yields. In addition, hitherto unknown β-aryl alkylselenocyanates were also synthesized using the developed protocol with potassium selenocyanate.

Photoredox-Catalyzed Intermolecular Radical Arylthiocyanation/Arylselenocyanation of Alkenes: Access to Aryl-Substituted Alkylthiocyanates/Alkylselenocyanates.

The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline–pyrrolidine/pyrrolothiazole/indolizine–oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives.

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles

Selectfluor-mediated mild oxidative halogenation and thiocyanation of 1-aryl-allenes with TMSX (X = Cl, Br, I, NCS) and NH4SCN

The direct α-thiocyanation of ketones with ammonium thiocyanate has been achieved using SelectfluorTM under mild and neutral conditions to produce α-ketothiocyanates, in excellent yields and with high selectivity.

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SelectfluorTM: A novel and efficient reagent for the rapid α-thiocyanation of ketones

A simple and efficient synthesis of spiro[pyrazolo[3,4-b]pyridine-4,3′-indoline] and spiro[benzo[h] pyrazolo[3,4-b]quinoline-4,3′-indoline] derivatives has been accomplished by the one-pot condensation of isatins, 3-methyl-1-phenyl-1H-pyrazol-5- amine and Meldrum’s acid or 2-hydroxy-1,4-naphthoquinone in the presence of wet cyanuric chloride as a catalyst under solvent-free conditions.

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Synthesis of spiro[pyrazolo[3,4-b] pyridine-4,3′-indoline] and spiro [benzo[h]pyrazolo[3,4-b]quinoline-4,3′-indoline] derivatives using wet cyanuric chloride under solvent-free conditionS

The title compounds (IV), (VI) are efficiently obtained by one-pot condensation of isatins, pyrazolamine and Meldrum′s acid or hydroxynaphthoquinone within relatively short reaction times.

Synthesis of Spiro[pyrazolo[3,4‐b]pyridine‐4,3′‐indoline] and Spiro[benzo[h]pyrazolo[3,4‐b]quinoline‐4,3′‐indoline] Derivatives Using Wet Cyanuric Chloride under Solvent‐Free Conditions.

Liqiang Wu

Papers

SelectfluorTM: A novel and efficient reagent for the rapid α-thiocyanation of ketones

Synthesis of spiro[pyrazolo[3,4-b] pyridine-4,3′-indoline] and spiro [benzo[h]pyrazolo[3,4-b]quinoline-4,3′-indoline] derivatives using wet cyanuric chloride under solvent-free conditionS

Synthesis of Spiro[pyrazolo[3,4‐b]pyridine‐4,3′‐indoline] and Spiro[benzo[h]pyrazolo[3,4‐b]quinoline‐4,3′‐indoline] Derivatives Using Wet Cyanuric Chloride under Solvent‐Free Conditions.

Selectfluor: A Novel and Efficient Reagent for the Rapid α‐Thiocyanation of Ketones.