Synthesis of spiro[pyrazolo[3,4-b] pyridine-4,3′-indoline] and spiro [benzo[h]pyrazolo[3,4-b]quinoline-4,3′-indoline] derivatives using wet cyanuric chloride under solvent-free conditionS
Reads0
Chats0
TLDR
In this article, a simple and efficient synthesis of spiro[pyrazolo[3,4-b]pyridine-4,3′-indoline] and spiro [benzo[h] pyrazolo [3, 4-b]-quinoline- 4, 3′indoline derivatives has been accomplished by the one-pot condensation of isatins, 3-methyl-1-phenyl-1H-pyrazol-5-amine and Meldrum's acid or 2-hydroxy-1, 4nAbstract:
A simple and efficient synthesis of spiro[pyrazolo[3,4-b]pyridine-4,3′-indoline] and spiro[benzo[h] pyrazolo[3,4-b]quinoline-4,3′-indoline] derivatives has been accomplished by the one-pot condensation of isatins, 3-methyl-1-phenyl-1H-pyrazol-5- amine and Meldrum’s acid or 2-hydroxy-1,4-naphthoquinone in the presence of wet cyanuric chloride as a catalyst under solvent-free conditions.read more
Citations
More filters
Journal ArticleDOI
Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles
Remani Vasudevan Sumesh,Muthumani Muthu,Abdulrahman I. Almansour,Raju Suresh Kumar,Natarajan Arumugam,Shunmuganarayanan Athimoolam,E. Arockia Jeya Yasmi Prabha,Raju Ranjith Kumar +7 more
TL;DR: The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline-pyrrolidine/ pyrrolothiazole/indolizine-oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-d
Journal ArticleDOI
The catalyst-free syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by one-pot, three-component reactions
TL;DR: In this article, the synthesis of tricyclic pyrazolo[3,4- b ]quinolin-5-one and pyrido[2,3- d ]pyrimidin-5,7-dione derivatives by cyclocondensation was reported.
Journal ArticleDOI
Use of 2,4,6-trichloro-1,3,5-triazine (TCT) as organic catalyst in organic synthesis
TL;DR: In recent years, 2,4,6-trichloro-1,3,5-triazine (TCT, cyanuric chloride) has been used as organic catalyst in many organic synthesis, because it is stable, nonvolatile, inexpensive, commercially available, and easy to handle.
References
More filters
BookDOI
Multicomponent Reactions: ZHU:MULTICOMPONENT REACTIONS O-BK
Jieping Zhu,Hugues Bienaymé +1 more
Journal ArticleDOI
Multiple-Component Condensation Strategies for Combinatorial Library Synthesis
TL;DR: This Account focuses on multiple-component condensations (MCCs) as one subset of strategies for the generation of compound libraries, and it is instructive to contrast this approach with linear synthesis to highlight the differences in methods, potential library size, and output format.
Journal ArticleDOI
Combinatorial synthesis : the design of compound libraries and their application to drug discovery
Journal ArticleDOI
Paraherquamides, brevianamides, and asperparalines: laboratory synthesis and biosynthesis. An interim report.
Robert M. Williams,Rhona J. Cox +1 more
TL;DR: Key biosynthetic studies are described, along with classical synthetic approaches as well as those inspired by Nature for the synthesis of these interesting molecules.
Journal ArticleDOI
Recent advances in multicomponent reactions for diversity-oriented synthesis
TL;DR: This review will highlight recent developments in MCRs as a rich source of molecular diversity as well as the discovery of new reactions, development of the first asymmetric catalysts, and the application of M CRs to natural products and other targets of biological interest.
Related Papers (5)
A simple and catalyst-free three-component method for the synthesis of spiro[indenopyrazolopyridine indoline]diones and spiro[indenopyridopyrimidine indoline]triones
Novel One-Pot, Three-Component Synthesis of Spiro[indoline-pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine]trione Library.
Facile Synthesis of Spiro[indoline-3,3′-pyrrolo[1,2-a]quinolines] and Spiro[indoline-3,1′-pyrrolo[2,1-a]isoquinolines] via 1,3-Dipolar Cycloaddition Reactions of Heteroaromatic Ammonium Salts with 3-Phenacylideneoxindoles.
Lei Wu,Jing Sun,Chao-Guo Yan +2 more