Longzheng Xia

TL;DR: Current understanding of the NFκB-signaling pathway in cancer is updated and targeted therapies against effectors in oncogenic signaling have improved the outcomes of cancer patients.

TL;DR: The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer Increased evidence suggests that cancer metabolism not only plays a crucial role in cancer signaling for sustaining tumorigenesis and survival, but also has wider implications in the regulation of the immune response through both the release of metabolites and affecting the expression of immune molecules, such as lactate, PGE2, arginine, etc.

TL;DR: This review article updates the colorectal CSCs with a focus on their role in tumor initiation, progression, drug resistance and tumor relapse.

TL;DR: This review summarizes recent progress in the understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.

TL;DR: The role of exosomal miRNAs in the process of TME reshaping is updated, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance.