Loren G. Lipson

TL;DR: Significant benefits for the OT preventive treatment group were found across various health, function, and quality-of-life domains, and suggest that preventive health programs based on OT may mitigate against the health risks of older adulthood.

TL;DR: The Well Elderly Study was a randomized trial in independent-living older adults that found significant health, function, and quality of life benefits attributable to a 9-month program in preventive occupational therapy.

TL;DR: The findings that glucose tolerance did not deteriorate with age, coupled with the lack of evidence for impaired β cell responsiveness to glucose in old males, suggest that deterioration in glucose homeostasis is not an inevitable consequence of aging in the mouse.

TL;DR: Data show that the impairment in glucose-induced insulin release in CRF is due to a defect in the metabolism of glucose, and the high [Ca2+]i in islets of CRF rats isdue to augmented PTH-induced calcium entry into cells and decreased calcium extrusion from the islets secondary to reduced activity of the Ca2+ ATPase.

TL;DR: The data show that pancreatic islets are a PTH target and may have PTH receptors, stimulation of glucose-induced insulin release by PTH is mediated by a rise in cytosolic calcium, 3) stimulation of cAMP production by P TH and a potential indirect activation of protein kinase C may also contribute to the stimulatory effect on glucose- induced insulin release, and 4) this action of PTH requires calcium in incubation or perifusion media.