L
Lorena Clay-Farrace
Researcher at University of Cambridge
Publications - 3
Citations - 2725
Lorena Clay-Farrace is an academic researcher from University of Cambridge. The author has contributed to research in topics: Cell cycle checkpoint & CHEK1. The author has an hindex of 3, co-authored 3 publications receiving 2516 citations.
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Journal ArticleDOI
A DNA damage checkpoint response in telomere-initiated senescence
Fabrizio d'Adda di Fagagna,Philip Michael Reaper,Lorena Clay-Farrace,Heike Fiegler,Philippa Carr,Thomas von Zglinicki,Gabriele Saretzki,Nigel P. Carter,Stephen P. Jackson +8 more
TL;DR: It is proposed that telomere-initiated senescence reflects a DNA damage checkpoint response that is activated with a direct contribution from dysfunctional telomeres.
Journal ArticleDOI
Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1
TL;DR: Evidence is provided that human Cdc6 (HuCdc6) also regulates the onset of mitosis, as overexpression of HuCDC6 in G2 phase cells prevents entry into mitosis and the ability of Hu cdc6 to block mitosis may be regulated by its phosphorylation.
Journal ArticleDOI
Regulatable killing of eukaryotic cells by the prokaryotic proteins Kid and Kis.
Guillermo de la Cueva-Méndez,Anthony D. Mills,Lorena Clay-Farrace,Ramón Díaz-Orejas,Ronald A. Laskey +4 more
TL;DR: This work reports that this toxin and antidote, which have evolved to function in bacteria, also function efficiently in a wide range of eukaryotes, and shows that Kid triggers apoptosis in human cells.