J
Jonathon Pines
Researcher at Institute of Cancer Research
Publications - 145
Citations - 23854
Jonathon Pines is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Mitosis & Cyclin A. The author has an hindex of 81, co-authored 138 publications receiving 22961 citations. Previous affiliations of Jonathon Pines include GE Healthcare & University of California, San Diego.
Papers
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Journal ArticleDOI
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
Tony Hunter,Jonathon Pines +1 more
Journal ArticleDOI
Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2
Jonathon Pines,Tony Hunter +1 more
TL;DR: The nucleotide and predicted amino acid sequence of a human B-type cyclin shows strong homology to the other known cyclins in the central third of the protein, and it is shown that the level of cyclin mRNA is regulated during the cell cycle.
Journal ArticleDOI
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.
Jonathon Pines,Tony Hunter +1 more
TL;DR: The different localization of cyclin A and cyclin B1 in the cell cycle could be the means by which the two types of mitotic cyclin confer substrate specificity upon their associated PSTAIRE-containing protein kinase subunit.
Journal ArticleDOI
Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis
Olivier Gavet,Jonathon Pines +1 more
TL;DR: It is demonstrated that different levels of CyclinB1-Cdk1 kinase activity trigger different mitotic events, thus revealing how the remarkable reorganization of the cell is coordinated at mitotic entry.