L
Lori Dowell
Publications - 2
Citations - 778
Lori Dowell is an academic researcher. The author has contributed to research in topics: Kinase & Receptor tyrosine kinase. The author has an hindex of 2, co-authored 2 publications receiving 760 citations.
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Journal ArticleDOI
Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors
Ultan McDermott,A. John Iafrate,Nathanael S. Gray,Toshi Shioda,Marie Classon,Shyamala Maheswaran,Wenjun Zhou,Hwan Geun Choi,Shannon Smith,Lori Dowell,Lindsey E. Ulkus,Georgiana Kuhlmann,Patricia Greninger,James G. Christensen,Daniel A. Haber,Jeffrey Settleman +15 more
TL;DR: Findings suggest that a subset of lung cancers, lymphomas, and neuroblastomas that harbor genomic ALK alterations may be clinically responsive to pharmacologic ALK inhibition.
Journal ArticleDOI
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
Ultan McDermott,Sreenath V. Sharma,Lori Dowell,Patricia Greninger,Clara Montagut,Jennifer Lamb,Heidi Archibald,Raul Raudales,Angela Tam,Diana Lee,S. Michael Rothenberg,Jeffrey G. Supko,Raffaella Sordella,Lindsey E. Ulkus,A. John Iafrate,Shyamala Maheswaran,Ching-Ni Njauw,Hensin Tsao,Lisa Drew,Jeff H. Hanke,Xiao-Jun Ma,Mark G. Erlander,Nathanael S. Gray,Daniel A. Haber,Jeffrey Settleman +24 more
TL;DR: Genetically defined cancer subsets, irrespective of tissue type, predict response to kinase inhibitors, and provide an important preclinical model to guide early clinical applications of novel targeted inhibitors.