Xiao-Jun Ma

TL;DR: The combined use of laser capture microdissection and DNA microarrays generate in situ gene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer, revealing extensive similarities at the transcriptome level among the distinct stages of progression.

TL;DR: The results suggest that the tumor microenvironment participates in tumorigenesis even before tumor cells invade into stroma, and that it may play important roles in the transition from preinvasive to invasive growth.

TL;DR: Genetically defined cancer subsets, irrespective of tissue type, predict response to kinase inhibitors, and provide an important preclinical model to guide early clinical applications of novel targeted inhibitors.

TL;DR: The combination of MGI and HOXB13:IL17BR outperforms either alone or alone and identifies a subgroup of early stage estrogen receptor–positive breast cancer patients with very poor outcome despite endocrine therapy.

TL;DR: This tumor bank study demonstrated HOXB13:IL17BR index is a strong independent prognostic factor for ER+ node-negative patients irrespective of tamoxifen therapy.