L
Lorraine Flaherty
Researcher at University of Texas Southwestern Medical Center
Publications - 7
Citations - 186
Lorraine Flaherty is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Gene & Antigen. The author has an hindex of 4, co-authored 7 publications receiving 186 citations. Previous affiliations of Lorraine Flaherty include Oklahoma State Department of Health.
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Journal ArticleDOI
Identification of a new CML target antigen controlled by a gene associated with the Qa-2 locus
James Forman,Lorraine Flaherty +1 more
TL;DR: There is no observedH-2 genetic restriction for this cytotoxic effect, since target cells which have theQa-2a allele but differ from the stimulator cells at the H-2K, D, andI regions were lysed efficiently.
Journal ArticleDOI
Qa-2, H-2K, and H-2D alloantigens evolved from a common ancestral gene.
TL;DR: The results show that the Qa-2 alloantigen is encoded by a locus separate from the loci encoding H-2K orH-2D alloants, but that theQa-1-5 and TL antigens are sufficiently related at the primary structural level to indicate that they evolved from a common primordial gene.
Journal ArticleDOI
The Qa2 subregion controls the expression of two antigens recognized by H-2-unrestricted cytotoxic T cells.
TL;DR: It is likely that Qa-2 and H-2 are derived from a common ancestral gene and have evolved to serve different functions as target antigens for unrestricted CTL and neither restricts antigen-specific CTL nor is polymorphie.
Journal ArticleDOI
MHC Class I gene organization in >1.5-Mb YAC contigs from the H2-M region
Elsy P. Jones,Hong Xiao,Roger A. Schultz,Lorraine Flaherty,Zdenek Trachtulec,Vladimir Vincek,Zoia Larin,Hans Lehrach,Kirsten Fischer Lindahl +8 more
TL;DR: The order among nine class I genes and seven other markers was determined in the cloned DNA from the centromere as T1, Tu32A, (M1-M7-M8), Tu32B, B30, M6, M4, M5, Mog, Tu42A parallel M2, Leh525, M3,Tu42B, where the orientation with respect to the centronere is unknown for M1- M7- M8.
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Biochemical analysis of an MHC‐linked hematopoietic cell surface antigen, Qa‐2
TL;DR: It is concluded that the Qa-2 alloantigen is structurally related to a class of cell surface molecules (ie, H-2) that play critical roles in immune recognition processes and further suggests that the genes encoding QA-2 and H-1-5 molecules have arisen from a common primordial gene.