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Louis-Charles Fortier

Researcher at Université de Sherbrooke

Publications -  65
Citations -  3502

Louis-Charles Fortier is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Clostridium difficile & Gene. The author has an hindex of 30, co-authored 56 publications receiving 2794 citations. Previous affiliations of Louis-Charles Fortier include Laval University & Faculté de médecine – Université de Sherbrooke.

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Journal ArticleDOI

Importance of prophages to evolution and virulence of bacterial pathogens

Louis-Charles Fortier, +1 more
- 23 Apr 2013 - 
TL;DR: The purpose of this review is to give an overview of the various ways by which prophages change the lifestyle and boost virulence of some of the most dangerous bacterial pathogens.
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PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data.

Julian R. Garneau, +7 more
- 15 Aug 2017 - 
TL;DR: A theoretical and statistical framework to determine DNA termini and phage packaging mechanisms using NGS data is developed and validated using a set of phages with well-established packaging mechanisms representative of the termini diversity.
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Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

Hugo Girard, +9 more
- 01 Aug 2004 - 
TL;DR: This is the first study to demonstrate that naturally occurring sequence variations in the UGT1A9 promoter are informative in predicting the levels of protein and glucuronidating activity, providing a potential mechanism for interindividual variation in UGT 1A9-mediated metabolism.
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Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and Flavopiridol Anticancer Drugs

Lyne Villeneuve, +4 more
- 01 Oct 2003 - 
TL;DR: Results suggest that these low SN-38 glucuronidating alleles may represent additional molecular determinants of irinotecan-induced toxicity and warrant further investigations.
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Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine-Related Metabolic Pathways

Jérôme Mulhbacher, +5 more
- 22 Apr 2010 - 
TL;DR: This work establishes the possibility of using existing structural knowledge to design novel guanine riboswitch-targeting antibiotics as powerful and selective antimicrobial compounds as well as identifying a pyrimidine compound that shows bactericidal activity against a subgroup of bacterial species including well-known nosocomial pathogens.