Louis G. D'Alecy

TL;DR: The volume-pressure recording (VPR) tail-cuff method provides accurate blood pressure measurements over the physiological range of blood pressure in mice by comparison to simultaneous radiotelemetry measurements.

TL;DR: Although reliable systolic pressure measurements are possible with either tail-cuff or radiotelemetry techniques, in some tail- cuff instruments fail to accurately detect elevated blood pressures, this study advises investigators to obtain an independent and simultaneous validation of tail-Cuff determinations of mouse blood pressure before making critical genotyping determinations.

TL;DR: The data suggest that oxidant injury has a major role in central nervous system dysfunction following successful resuscitation from 9 min of cardiac arrest and resuscitating from cardiac arrest with hyperoxic FIO2's may contribute to and further exacerbate neurologic dysfunction.

TL;DR: It is demonstrated that PPargamma is required to maintain normal adiposity and insulin sensitivity in adult mice and genetic loss of PPARgamma function, like activation by agonists, lowered blood pressure, likely through a mechanism involving increased vascular relaxation.

TL;DR: Reduction in cortical brain lactate during ischemia cannot account for the postischemic functional protection afforded by preischemics selective brain cooling, and thus accounts for imporved neurologic outcome after complete cerebral ischemIA in dogs.