L
Louise Royle
Researcher at University College Dublin
Publications - 97
Citations - 7170
Louise Royle is an academic researcher from University College Dublin. The author has contributed to research in topics: Glycan & Glycosylation. The author has an hindex of 45, co-authored 97 publications receiving 6672 citations. Previous affiliations of Louise Royle include University of Oxford.
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Journal ArticleDOI
HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software.
Louise Royle,Matthew Campbell,Matthew Campbell,Catherine M. Radcliffe,Catherine M. Radcliffe,Dawn M. White,David Harvey,Jodie L. Abrahams,Yun-Gon Kim,George Henry,Nancy A. Shadick,Michael E. Weinblatt,David M. Lee,Pauline M. Rudd,Pauline M. Rudd,Raymond A. Dwek +15 more
TL;DR: A robust, fully automatable technology platform that includes computer software for the detailed analysis of low femtomoles of N-linked sugars released from glycoproteins is presented, allowing optimization of production conditions and its application to rheumatoid arthritis is demonstrated.
Journal ArticleDOI
Ovarian Cancer is Associated With Changes in Glycosylation in Both Acute-Phase Proteins and IgG
Radka Saldova,Louise Royle,Catherine M. Radcliffe,Umi Marshida Abd Hamid,Rachel Evans,James N. Arnold,Rosamonde E. Banks,Richard Hutson,David Harvey,Robin Antrobus,Stefana M. Petrescu,Raymond A. Dwek,Pauline M. Rudd,Pauline M. Rudd +13 more
TL;DR: There was some preliminary indication that combinations of changes in the serum glycome might improve the separation of ovarian cancer and benign tumors; however, a larger study using data receiver operating characteristic curves will be required to draw any firm conclusions.
Journal ArticleDOI
Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumor origins.
Rosa Peracaula,Glòria Tabarés,Louise Royle,David Harvey,Raymond A. Dwek,Pauline M. Rudd,Rafael de Llorens +6 more
TL;DR: In this paper, N-glycan characterization of PSA from seminal fluid and prostate cancer cells (LNCaP cell line) by sequencing analysis and mass spectrometry was carried out.
Journal ArticleDOI
Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems.
Louise Royle,Anja Roos,David Harvey,Mark R. Wormald,Daniëlle J. van Gijlswijk-Janssen,Elrashdy M. Redwan,Ian A. Wilson,Mohamed R. Daha,Raymond A. Dwek,Pauline M. Rudd +9 more
TL;DR: It is shown that the N-glycans on the H chains of both SIgA1 andSIgA2 present terminal GlcNAc and mannose residues that are normally masked by SC, but that can be unmasked and recognized byMannose-binding lectin, by disrupting the SC-H chain noncovalent interactions.
Journal ArticleDOI
GlycoBase and autoGU
TL;DR: A database (GlycoBase) and analytical tool (autoGU) to assist the interpretation and assignment of HPLC-glycan profiles to facilitate basic research as well as the quantitative high-throughput analysis of low concentrations of glycans released from glycoproteins.