Lu Zhao

TL;DR: In a number of human and murine cells and cancers, Myc induces elevated expression of glutamate-ammonia ligase (GLUL), also termed glutamine synthetase (GS), which catalyzes the de novo synthesis of glutamine from glutamate and ammonia.

TL;DR: Bartender is a set of simple‐to‐use command line tools that can be performed on a laptop at comparable run times to existing methods that cluster based on sequence similarity alone, and uses a modified two‐sample proportion test that also considers cluster size.

TL;DR: The data define the first physiologically relevant function of BLVRB and implicate its activity and/or heme-regulated BV tetrapyrrole(s) in a unique redox-regulated bioenergetic pathway governing terminal megakaryocytopoiesis; these observations also define a mechanistically restricted drug target retaining potential for enhancing human platelet counts.

TL;DR: It is observed that the selected mRNAs are highly relevant to ET disease, and provide an initial framework for dissecting both platelet-enhancing and functional consequences of dysregulated platelet production.

TL;DR: New approximation algorithms for robot routing problems that are variants of the classical traveling salesperson problem (TSP) are given, giving paths whose lengths are within a bounded factor of the optimal length.