L
Luc Kestens
Researcher at Institute of Tropical Medicine Antwerp
Publications - 178
Citations - 5554
Luc Kestens is an academic researcher from Institute of Tropical Medicine Antwerp. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 39, co-authored 161 publications receiving 5340 citations. Previous affiliations of Luc Kestens include University of Antwerp.
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Journal ArticleDOI
Prospective Comparison of Mother-to-Child Transmission of HIV-1 and HIV-2 in Abidjan, Ivory Coast
Georgette Adjorlolo-Johnson,Kevin M. De Cock,Ehounou R. Ekpini,Vetter Km,Toussaint S. Sibailly,K. Brattegaard,Daniel Yavo,Doorly R,J. Patrick Whitaker,Luc Kestens,Chin-Yih Ou,J. Richard George,Gayle Hd +12 more
TL;DR: The rate of perinatal transmission of HIV-2 was much lower than the rate ofPerinatal transmitted HIV-1, and this was associated with more favorable survival for infants ofAIDS-2-infected mothers, and public health guidelines should incorporate advice that perinnatal transmission of AIDS-2 is rare.
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The Replicative Fitness of Primary Human Immunodeficiency Virus Type 1 (HIV-1) Group M, HIV-1 Group O, and HIV-2 Isolates
Kevin K. Ariën,Awet Abraha,Miguel E. Quiñones-Mateu,Luc Kestens,Guido Vanham,Guido Vanham,Eric J. Arts +6 more
TL;DR: Results suggest that reduced replicative and transmission fitness may be contributing to the low prevalence and limited geographical spread of HIV-2 and group O HIV-1 in the human population.
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Generalized immune activation in pulmonary tuberculosis: co‐activation with HIV infection
Guido Vanham,K. Edmonds,L. Qing,D. Hom,Zahra Toossi,B. Jones,C. L. Daley,R. Huebner,Luc Kestens,P. Gigase,Jerrold J. Ellner +10 more
TL;DR: The expression of HLA‐DR on T cell subsets and of FcγR on monocytes correlated with each other, but not with serum activation markers, suggesting a pattern of non‐specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.
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Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection.
Luc Kestens,Guido Vanham,P. Gigase,Gloria Young,Irene Hannet,Francis Vanlangendonck,Frank Hulstaert,Bruce Allen Bach +7 more
TL;DR: There is a stage-associated pattern of HLA-DR and CD38 expression on CD8 T-lymphocytes during HIV infection; specific phenotypic patterns may have functional correlates in the host response to the virus.
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Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands.
Wim Jennes,Sonja Verheyden,Christian Demanet,Christiane Adjé-Touré,Bea Vuylsteke,John N. Nkengasong,Luc Kestens +6 more
TL;DR: The data support an important role for NK cells and KIR/HLA interactions in antiviral immunity and suggest absence of ligands for inhibitory KIR could lower the threshold for NK cell activation.