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Luca Jaromi

Researcher at University of Pécs

Publications -  33
Citations -  860

Luca Jaromi is an academic researcher from University of Pécs. The author has contributed to research in topics: Population & Allele frequency. The author has an hindex of 15, co-authored 33 publications receiving 773 citations.

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Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis

TL;DR: There is direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn’s disease, but not for scleroderma.
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WNT signaling – lung cancer is no exception

TL;DR: The various effects of activation and inhibition of the WNT signaling pathways are summarized in the context of lung carcinogenesis and the role of WNT ligand transport mechanisms is reviewed.
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Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjögren syndrome in Hungarian population samples.

TL;DR: The susceptibility or protective associations of IL23R polymorphisms with AS in a Hungarian population are confirmed and the involvement of the rs11805303 intronic single nucleotide polymorphisms, which was tested so far only for other autoimmune diseases is demonstrated.
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Apolipoprotein A5 T-1131C variant confers risk for metabolic syndrome.

TL;DR: Findings strongly suggest that this variant of the ApoA5 –1131C gene is a risk factor for the development of hypertriglyceridemia and metabolic syndrome.
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ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling.

TL;DR: The difference in the Wnt microenvironment in AC and SCC leads to variations in ABC transporter expression, and cisplatin, the frequently used adjuvant chemotherapeutic agent, activated beta-catenin dependent signaling that lead to up-regulation of both ABCB1 and ABCG2 transporter expression and activity.