C
Csilla Sipeky
Researcher at University of Turku
Publications - 63
Citations - 2190
Csilla Sipeky is an academic researcher from University of Turku. The author has contributed to research in topics: Population & Prostate cancer. The author has an hindex of 21, co-authored 62 publications receiving 1554 citations. Previous affiliations of Csilla Sipeky include University of Pécs & UCB.
Papers
More filters
Journal ArticleDOI
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Fredrick R. Schumacher,Ali Amin Al Olama,Sonja I. Berndt,Sara Benlloch,Mahbubl Ahmed,Edward J. Saunders,Tokhir Dadaev,Daniel Leongamornlert,Ezequiel Anokian,Clara Cieza-Borrella,Chee Goh,Mark N. Brook,Xin Sheng,Laura Fachal,Joe Dennis,Jonathan Tyrer,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Artitaya Lophatananon,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Jyotsna Batra,Jyotsna Batra,Suzanne K. Chambers,Suzanne K. Chambers,Leire Moya,Leire Moya,Judith A. Clements,Judith A. Clements,Lisa G. Horvath,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Tobias Nordström,Paul D.P. Pharoah,Nora Pashayan,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Demetrius Albanes,Stephanie J. Weinstein,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Catharine M L West,Alison M. Dunning,Neil G. Burnet,Lorelei A. Mucci,Edward Giovannucci,Gerald L. Andriole,Olivier Cussenot,Geraldine Cancel-Tassin,Stella Koutros,Laura E. Beane Freeman,Karina Dalsgaard Sørensen,Torben F. Ørntoft,Michael Borre,Lovise Maehle,Eli Marie Grindedal,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Ruth C. Travis,Timothy J. Key,Robert J. Hamilton,Neil E. Fleshner,Antonio Finelli,Sue A. Ingles,Mariana C. Stern,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Xin Guo,Guomin Wang,Zan Sun,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Liesel M. FitzGerald,Liesel M. FitzGerald,Adam S. Kibel,Bettina F. Drake,Ana Vega,Antonio Gómez-Caamaño,Robert Szulkin,Martin Eklund,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Kathryn L. Penney,Meir J. Stampfer,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Janet L. Stanford,Janet L. Stanford,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,Elaine A. Ostrander,Milan S. Geybels,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Rasmus Bisbjerg,Martin Andreas Røder,Peter Iversen,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Christiane Maier,Manuel Luedeke,Thomas J. Schnoeller,Jeri Kim,Christopher J. Logothetis,Esther M. John,Esther M. John,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Marta Cardoso,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,Kim De Ruyck,Gert De Meerleer,Piet Ost,Azad Hassan Abdul Razack,Jasmine Lim,Soo Hwang Teo,Daniel W. Lin,Daniel W. Lin,Lisa F. Newcomb,Lisa F. Newcomb,Davor Lessel,Marija Gamulin,Tomislav Kuliš,Radka Kaneva,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Sandeep Singhal,Chavdar Slavov,Vanio Mitev,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Samantha E.T. Larkin,Paul A. Townsend,Claire Aukim-Hastie,Manuela Gago Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Jianfeng Xu,Kay-Tee Khaw,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hardev Pandha,Agnieszka Michael,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Sara Lindström,Constance Turman,Jing Ma,David J. Hunter,Elio Riboli,A. Siddiq,Federico Canzian,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Zuxi Cui,Peter Kraft,Christopher I. Amos,David V. Conti,Douglas F. Easton,Fredrik Wiklund,Stephen J. Chanock,Brian E. Henderson,Zsofia Kote-Jarai,Christopher A. Haiman,Rosalind A. Eeles +207 more
TL;DR: A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.
Journal ArticleDOI
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
David V. Conti,Burcu F. Darst,Lilit C. Moss,Edward J. Saunders,Xin Sheng,Alisha Chou,Fredrick R. Schumacher,Ali Amin Al Olama,Sara Benlloch,Tokhir Dadaev,Mark N. Brook,Ali Sahimi,Thomas J. Hoffmann,Atushi Takahashi,Koichi Matsuda,Yukihide Momozawa,Masashi Fujita,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Peggy Wan,Loic Le Marchand,Lynne R. Wilkens,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Graham G. Giles,Graham G. Giles,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Stig E. Bojesen,Martin Andreas Røder,Peter Iversen,Jyotsna Batra,Suzanne K. Chambers,Leire Moya,Lisa G. Horvath,Judith A. Clements,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Robert Szulkin,Martin Eklund,Tobias Nordström,Nora Pashayan,Alison M. Dunning,Maya Ghoussaini,Ruth C. Travis,Timothy J. Key,Elio Riboli,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Demetrius Albanes,Stephanie J. Weinstein,Lorelei A. Mucci,Edward Giovannucci,Sara Lindström,Peter Kraft,David J. Hunter,Kathryn L. Penney,Constance Turman,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Robert J. Hamilton,Robert J. Hamilton,Neil Fleshner,Antonio Finelli,Marie-Élise Parent,Marie-Élise Parent,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Milan S. Geybels,Stella Koutros,Laura E. Beane Freeman,Meir J. Stampfer,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Gerald L. Andriole,Robert N. Hoover,Mitchell J. Machiela,Karina Dalsgaard Sørensen,Michael Borre,William J. Blot,Wei Zheng,Edward D. Yeboah,Edward D. Yeboah,James E. Mensah,James E. Mensah,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Yudong Wu,Shan Chao Zhao,Zan Sun,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Catharine M L West,Neil G. Burnet,Gill Barnett,Christiane Maier,Thomas J. Schnoeller,Manuel Luedeke,Adam S. Kibel,Bettina F. Drake,Olivier Cussenot,Geraldine Cancel-Tassin,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Esther M. John,Eli Marie Grindedal,Lovise Maehle,Kay-Tee Khaw,Sue A. Ingles,Mariana C. Stern,Ana Vega,Antonio Gómez-Caamaño,Laura Fachal,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Andreia Brandão,Stephen Watya,Alexander Lubwama,Jeannette T. Bensen,Elizabeth T. H. Fontham,James L. Mohler,James L. Mohler,Jack A. Taylor,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Craig C. Teerlink,Craig C. Teerlink,Chad D. Huff,Sara S. Strom,Luc Multigner,Pascal Blanchet,Laurent Brureau,Radka Kaneva,Chavdar Slavov,Vanio Mitev,Robin J. Leach,Brandi Weaver,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Kai Uwe Saum,Eric A. Klein,Ann W. Hsing,Rick A. Kittles,Adam B. Murphy,Christopher J. Logothetis,Jeri Kim,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,William B. Isaacs,Barbara Nemesure,Anselm Hennis,Anselm Hennis,John D. Carpten,Hardev Pandha,Agnieszka Michael,Kim De Ruyck,Gert De Meerleer,Piet Ost,Jianfeng Xu,Azad Hassan Abdul Razack,Jasmine Lim,Soo-Hwang Teo,Lisa F. Newcomb,Daniel W. Lin,Jay H. Fowke,Christine Neslund-Dudas,Benjamin A. Rybicki,Marija Gamulin,Davor Lessel,Tomislav Kuliš,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Manuela Gago-Dominguez,Manuela Gago-Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Samantha E.T. Larkin,Paul A. Townsend,Paul A. Townsend,Claire Aukim-Hastie,William S. Bush,Melinda C. Aldrich,Dana C. Crawford,Shiv Srivastava,Jennifer Cullen,Gyorgy Petrovics,Graham Casey,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Jennifer J. Hu,Maureen Sanderson,Rohit Varma,Roberta McKean-Cowdin,Mina Torres,Nicholas Mancuso,Sonja I. Berndt,Stephen K. Van Den Eeden,Stephen K. Van Den Eeden,Douglas F. Easton,Stephen J. Chanock,Michael B. Cook,Fredrik Wiklund,Hidewaki Nakagawa,John S. Witte,Rosalind A. Eeles,Rosalind A. Eeles,Zsofia Kote-Jarai,Christopher A. Haiman +254 more
TL;DR: This paper conducted a meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants.
Journal ArticleDOI
Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts
Tyler M. Seibert,Chun Chieh Fan,Yunpeng Wang,Verena Zuber,Verena Zuber,Roshan Karunamuni,J. Kellogg Parsons,Rosalind A. Eeles,Douglas F. Easton,Zsofia Kote-Jarai,Ali Amin Al Olama,Sara Benlloch Garcia,Kenneth Muir,Kenneth Muir,Henrik Grönberg,Fredrik Wiklund,Markus Aly,Johanna Schleutker,Johanna Schleutker,Csilla Sipeky,Teuvo L.J. Tammela,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Rasmus Bisbjerg,M. Andreas Røder,Peter Iversen,Timothy J. Key,Ruth C. Travis,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Paul D.P. Pharoah,Nora Pashayan,Nora Pashayan,Kay-Tee Khaw,Christiane Maier,Walther Vogel,Manuel Luedeke,Kathleen Herkommer,Adam S. Kibel,Cezary Cybulski,Dominika Wokołorczyk,Wojciech Kluzniak,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Katarina Cuk,Kai Uwe Saum,Jong Y. Park,Thomas A. Sellers,Chavdar Slavov,Radka Kaneva,Vanio Mitev,Jyotsna Batra,Judith A. Clements,Amanda B. Spurdle,Amanda B. Spurdle,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Sofia Maia,Hardev Pandha,Agnieszka Michael,Andrzej M. Kierzek,David S. Karow,Ian G. Mills,Ian G. Mills,Ian G. Mills,Ole A. Andreassen,Anders M. Dale +71 more
TL;DR: Polygenic hazard scores can be used for personalised genetic risk estimates that can predict for age at onset of aggressive PCa in men participating in international PRACTICAL consortium.
Journal ArticleDOI
Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis
Bernadett Faragó,Lili Magyari,Eniko Safrany,Veronika Csöngei,Luca Jaromi,Katalin Horvatovich,Csilla Sipeky,Anita Maász,Judit Radics,Ágnes Gyetvai,Zoltán Szekanecz,László Czirják,Béla Melegh +12 more
TL;DR: There is direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn’s disease, but not for scleroderma.
Journal ArticleDOI
Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus
Ping Gao,Jihan Xia,Csilla Sipeky,Xiao-Ming Dong,Qin Zhang,Yuehong Yang,Peng Zhang,Sara Pereira Cruz,Kai Zhang,Jing Zhu,Hang-Mao Lee,Sufyan Suleman,Nikolaos Giannareas,Song Liu,Teuvo L.J. Tammela,Anssi Auvinen,Xiaoyue Wang,Qilai Huang,Liguo Wang,Aki Manninen,Markku H. Vaarala,Liang Wang,Johanna Schleutker,Gong-Hong Wei +23 more
TL;DR: Clinical data demonstrated synergistic effects of rs11672691 genotype and PCAT19/CEACAM21 gene expression on PCa prognosis and CRISPR/Cas9-mediated single-nucleotide editing provided a plausible mechanism for rs11 672691 associated with aggressive PCa and thus lay the ground work for translating this finding to the clinic.