Lucia Chiummiento

TL;DR: Highly chemoselective reduction of the azido alcohol led to a key compound which was utilized for the synthesis of two analogues of commercial anti HIV PR such as nelfinavir and saquinavir.

TL;DR: Differently protected glycidol derivatives (with Bn, TBDPS, TBS and MPM groups) were tested for regioselective ring opening with vinylmagnesium bromide in order to obtain useful five-carbon functionalised homoallylic alcohols as mentioned in this paper.

TL;DR: Since the fluorene chromophore leads to the presence of several Cotton effects from, say, 350 to 200 nm, their correct simulation of sign, intensity, and position is a guarantee of the correct assignment of AC: in this way, ECD spectroscopy gains the same advantages of VCDSpectroscopy, that is, the need of reproducing many ECD bands and then a solid guarantee of a correct AC assignment.

TL;DR: The convergent synthesis of the C12-C24 fragment (lower part) of macrolactin A is described, and reductive elimination of the appropriate allylic dibenzoate with Na/Hg introduced directly the C16-C19 (E,E)-diene unit, in a highly efficient stereoselective fashion.

TL;DR: This is the first report about the evaluation of significant biological activities and phytochemical profile of A. glabra, an important source of health-promoting phytochemicals in Andean region of South America to treat various chronic diseases.