Luigi Gennari

TL;DR: A further promising application of these polymorphisms comes from their pharmacogenomic implications, with the possibility of providing better guidance for therapeutic regimens, such as estrogen replacement therapy and selective ER modulators.

TL;DR: Results from the present study indicate an important role of estrogens, and particularly of the ability to aromatize T to E(2), in the regulation of bone loss and bone metabolism in elderly men.

TL;DR: The introduction of another variable, the ER genotype, in the analysis of VDR genetic determination of BMD, may represent a useful model in the identification of patients at risk of developing a multigenic disorder like osteoporosis.

TL;DR: Findings suggest that sclerostin is increased in DM2, a condition of low bone turnover and decreased osteoblast activity in both type 1 and 2 diabetes mellitus, and the transcriptional suppression of sclerOSTin production by PTH might be impaired in both DM1 and DM2.

TL;DR: In this article, the authors evaluated the effect of the XbaI and PvuII polymorphisms of the estrogen receptor a to BMD and fracture risk in a meta-analysis, including published data and additional information from investigators Five thousand eight hundred thirty-four women from 30 study groups were analyzed with fixed and random effects models.