L
Luis Carvalho
Researcher at AgResearch
Publications - 79
Citations - 1589
Luis Carvalho is an academic researcher from AgResearch. The author has contributed to research in topics: Posterior probability & Missing data. The author has an hindex of 18, co-authored 74 publications receiving 1250 citations. Previous affiliations of Luis Carvalho include Spanish National Research Council & Brown University.
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Journal ArticleDOI
Tropical forests are a net carbon source based on aboveground measurements of gain and loss
Alessandro Baccini,Wayne S. Walker,Luis Carvalho,Mary Farina,Damien Sulla-Menashe,Richard A. Houghton +5 more
TL;DR: 12 years of MODIS satellite data are used to quantify net annual changes in the aboveground carbon density of tropical woody live vegetation, providing direct, measurement-based evidence that the world’s tropical forests are a net carbon source.
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Centroid estimation in discrete high-dimensional spaces with applications in biology
TL;DR: It is shown that centroid estimates are obtained by maximizing the marginal probabilities of the solution components for unconstrained ensembles and for an important class of problems, including sequence alignment and the prediction of RNA secondary structure, whoseEnsembles contain exclusivity constraints.
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Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis
Luis Carvalho,Juan Román Luque-Ortega,José Ignacio Manzano,Santiago Castanys,Luis Rivas,Francisco Gamarro +5 more
TL;DR: It is concluded that TFQ targets Leishmania mitochondria, leading to an apoptosis-like death process and may represent an alternative treatment for leishmaniasis.
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Low Plasma Membrane Expression of the Miltefosine Transport Complex Renders Leishmania braziliensis Refractory to the Drug
María P. Sánchez-Cañete,Luis Carvalho,F. Javier Pérez-Victoria,Francisco Gamarro,Santiago Castanys +4 more
TL;DR: The results further highlight the importance of the MLF translocation machinery in determining MLF potency and point toward the development of protocols to routinely monitor MLF susceptibility in geographic areas where L. braziliensis might be prevalent.
Journal ArticleDOI
The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase.
Luis Carvalho,Juan Román Luque-Ortega,Carmen López-Martín,Santiago Castanys,Luis Rivas,Francisco Gamarro +5 more
TL;DR: Results support a lethal mechanism for SQ that involves inhibition of the respiratory chain complex II, which in turn triggers oxidative stress and finally leads to an apoptosis-like death of Leishmania parasites.