Luisa Aran

TL;DR: Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions.

TL;DR: Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation.

TL;DR: The authors describe the mechanisms of cardiotoxicity induced by anthracyclines, which can lead to cardiovascular problems in up to 48% of patients who take them, and outline the recent advances in immunotherapies, which have revolutionised anticancer therapies.

TL;DR: OH is a common condition in frail older adults, and it is strongly associated with mortality, disability, and hospitalization in the highest frailty degree, and may represent a new marker of clinical frailty.

TL;DR: It has been described that light frailty is related to good outcomes in older adults and frailty status should be routinely and correctly quantified in order to identify the frailty degree and to find the best harms–benefits balance of antihypertensive drug treatment in frail older adults.