L
Luisa Scaglia
Researcher at Brigham and Women's Hospital
Publications - 8
Citations - 1689
Luisa Scaglia is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Islet & Transplantation. The author has an hindex of 6, co-authored 8 publications receiving 1640 citations. Previous affiliations of Luisa Scaglia include Harvard University.
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Journal ArticleDOI
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.
TL;DR: A mathematical model of the dynamics of the β-cell mass in the normal growing rat pancreas is constructed to infer the contributions of fluxes that cannot be measured, i.e., neogenesis and cell death, to the known mass of β-cells.
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Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function
Alberto M. Davalli,Luisa Scaglia,David Zangen,Jennifer Hollister,Susan Bonner-Weir,Gordon C. Weir +5 more
TL;DR: The first few days of islet transplantation, even under the most advantageous circumstances of excellent metabolic control, are characterized by dynamic changes, with substantial islet cell dysfunction and death followed by tissue remodeling and then stable engraftment.
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Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat
TL;DR: The data show that the endocrine pancreas undergoes significant modification during neonatal life and that apoptosis is an important mechanism in this remodeling of the beta cell mass.
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Function, Mass, and Replication of Porcine and Rat Islets Transplanted into Diabetic Nude Mice
Alberto M. Davalli,Yoshiji Ogawa,Luisa Scaglia,Ying-Jian Wu,Jennifer Hollister,Susan Bonner-Weir,Gordon C. Weir +6 more
TL;DR: Evidence that adult porcine islet grafts can bring glucose levels to those that are normal for humans provides further support of their potential for human islet replacement therapy.