Showing papers by "Luke Y.C. Chen published in 2004"
TL;DR: The thiophilic nature of bismuth implicates sulfur centers as likely sites for interaction, and this feature is exploited to identify, isolate, and characterize complexes ofbismuth with thiolate-carboxylate bifunctional ligands including the amino acid l-cysteine.
Abstract: Although bismuth compounds have been used in medicine for over 200 years, chemical characterization of complexes involving biological molecules is minimal and mechanisms of bioactivity are ill-defined. The thiophilic nature of bismuth implicates sulfur centers as likely sites for interaction, and we have exploited this feature to identify, isolate, and characterize complexes of bismuth with thiolate−carboxylate bifunctional ligands including the amino acid l-cysteine. The solid-state structures of potassium dichloro(thiopropionato)bismuth (K[1d]), dimethylaminoethanethiolato(thiopropionato)bismuth (4), and dinitrato(cysteinato)bismuthphenanthroline [5(phen)] are compared with data from electrospray ionization mass spectrometry (ESI-MS). ESI-MS is applied to reactions of BiCl3 or Bi(NO3)3 with mercaptosuccinic, malic, and succinic acids to illustrate the general observation of 1:1 and 1:2 complexes.
43 citations