L
Lutz Schmitt
Researcher at University of Düsseldorf
Publications - 202
Citations - 7303
Lutz Schmitt is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: ATP-binding cassette transporter & Secretion. The author has an hindex of 42, co-authored 182 publications receiving 6144 citations. Previous affiliations of Lutz Schmitt include University of Paris & University of Marburg.
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Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance.
TL;DR: Amino acids involved in phosphorylation, dimerization, and DNA-binding were identified and demonstrated to be conserved in lantibiotic resistance regulators and a model of the full-length NsrR in the active and inactive state provides insights into protein dimerized andDNA-binding.
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Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation.
Philipp Ellinger,Jan Stindt,Carola Dröge,Katharina Sattler,Claudia Stross,Stefanie Kluge,Diran Herebian,Sander H. J. Smits,Martin Burdelski,Sebastian Schulz-Jürgensen,Antje Ballauff,Jan Schulte am Esch,Ertan Mayatepek,Dieter Häussinger,Ralf Kubitz,Lutz Schmitt +15 more
TL;DR: It is suggested that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2 (PFIC-2).
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Analysis of the Bile Salt Export Pump (ABCB11) Interactome Employing Complementary Approaches.
Susanne Przybylla,Jan Stindt,Diana Kleinschrodt,Jan Schulte am Esch,Dieter Häussinger,Verena Keitel,Sander H. J. Smits,Lutz Schmitt +7 more
TL;DR: Ten novel BSEP interaction partners were identified including proteins of the early secretory pathway and the bile acyl-CoA synthetase, the second to last, ER-associated enzyme of bile salt synthesis.
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Impact of the nisin modification machinery on the transport kinetics of NisT.
TL;DR: This study highlights the pivotal role of NisB for NisT in the secretion process in the presence and absence of the nisin maturation machinery, consisting of the dehydratase N isB and the cyclase NisC.
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Microseeding – A Powerful Tool for Crystallizing Proteins Complexed with Hydrolyzable Substrates
TL;DR: A microseeding protocol is devised leading to crystals of ChoX with bound acetylcholine within 24 hours, with one drawback the high twinning fraction of the crystals, possibly was due to the rapid crystal growth.