L
Lynda S. Wright
Researcher at University of Wisconsin-Madison
Publications - 48
Citations - 3536
Lynda S. Wright is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Calmodulin & Neural stem cell. The author has an hindex of 25, co-authored 48 publications receiving 3285 citations.
Papers
More filters
Journal ArticleDOI
Modeling early retinal development with human embryonic and induced pluripotent stem cells.
Jason S. Meyer,R. L. Shearer,Elizabeth E. Capowski,Lynda S. Wright,Kyle Wallace,Erin McMillan,Su-Chun Zhang,David M. Gamm +7 more
TL;DR: The ability of both human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells to meet requirements for human retinogenesis are demonstrated.
Journal ArticleDOI
Optic Vesicle-like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment
Jason S. Meyer,Sara E. Howden,Sara E. Howden,Kyle Wallace,Amelia D. Verhoeven,Lynda S. Wright,Elizabeth E. Capowski,Isabel Pinilla,Jessica M. Martin,Shulan Tian,Ron Stewart,Bikash R. Pattnaik,James A. Thomson,David M. Gamm +13 more
TL;DR: It is demonstrated that three‐dimensional populations of retinal progenitor cells (RPCs) can be isolated from early forebrain populations in both human embryonic stem cell and hiPSC cultures, providing a valuable tool for developmental, functional, and translational studies.
Journal ArticleDOI
Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells.
Jiang Li,Delinda A. Johnson,Marcus J. Calkins,Lynda S. Wright,Clive N. Svendsen,Jeffrey S. Johnson +5 more
TL;DR: This study suggests that identified antioxidant genes, which were upregulated through tBHQ induced Nrf2 stabilization, confer protection on target cells against H2O2-induced apoptotic cell death in neuroblastoma cells as well as the necrotic cellDeath in the hNSC.
Journal ArticleDOI
iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration
Ruchira Singh,Wei Shen,David Kuai,Jessica M. Martin,Xiangrong Guo,Molly A. Smith,Enio T. Perez,M. Joseph Phillips,Joseph M. Simonett,Kyle Wallace,Amelia D. Verhoeven,Elizabeth E. Capowski,Xiaoqing Zhang,Yingnan Yin,Patrick Halbach,Gerald A. Fishman,Lynda S. Wright,Bikash R. Pattnaik,David M. Gamm +18 more
TL;DR: The potential to use patient-specific hiPSCs to model and study maculopathies, an important class of blinding disorders in humans, is demonstrated.
Journal ArticleDOI
Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses.
M. Joseph Phillips,Kyle Wallace,Sarah Jane Dickerson,Michael J. Miller,Amelia D. Verhoeven,Jessica M. Martin,Lynda S. Wright,Wei Shen,Elizabeth E. Capowski,E. Ferda Percin,Enio T. Perez,Xiufeng Zhong,Maria V. Canto-Soler,David M. Gamm +13 more
TL;DR: It is demonstrated for the first time that human blood-derived iPSCs can generate retinal cell types, providing a highly convenient donor cell source for iPSC-based retinal studies and showing that cultured TiPSCs have the capacity to self-assemble into rudimentary neuroretinal structures and express markers indicative of chemical and electrical synapses.