L
Lynne Williams
Researcher at Papworth Hospital
Publications - 70
Citations - 2197
Lynne Williams is an academic researcher from Papworth Hospital. The author has contributed to research in topics: Hypertrophic cardiomyopathy & Heart failure. The author has an hindex of 24, co-authored 67 publications receiving 1898 citations. Previous affiliations of Lynne Williams include University Health Network & University of Birmingham.
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Journal ArticleDOI
Metabolic Modulation With Perhexiline in Chronic Heart Failure A Randomized, Controlled Trial of Short-Term Use of a Novel Treatment
Leong Lee,Ross T. Campbell,Michaela Scheuermann-Freestone,Rachel Taylor,Prasad Gunaruwan,Lynne Williams,Houman Ashrafian,John D. Horowitz,Alan G. Fraser,Kieran Clarke,Michael P. Frenneaux +10 more
TL;DR: In patients with CHF, metabolic modulation with perhexiline improved &OV0312;o2max, left ventricular ejection fraction, symptoms, resting and peak stress myocardial function, and skeletal muscle energetics, and per hexiline may represent a novel treatment for CHF with a good safety profile.
Journal ArticleDOI
Heart Failure With Preserved Ejection Fraction Is Characterized by Dynamic Impairment of Active Relaxation and Contraction of the Left Ventricle on Exercise and Associated With Myocardial Energy Deficiency
Thanh T. Phan,Khalid Abozguia,Ganesh Nallur Shivu,G. Mahadevan,Ibrar Ahmed,Lynne Williams,Girish Dwivedi,Kiran Patel,Paul Steendijk,Houman Ashrafian,Anke Henning,Michael P. Frenneaux +11 more
TL;DR: Patients with HFpEF have reduced cardiac energetic reserve that may underlie marked dynamic slowing of LV active relaxation and abnormal VVC during exercise.
Journal ArticleDOI
Myocardial Fibrosis in Hypertrophic Cardiomyopathy: Accurate Reflection of Histopathological Findings by CMR
Gil Moravsky,Efrat Ofek,Harry Rakowski,Jagdish Butany,Lynne Williams,Anthony Ralph-Edwards,Bernd J. Wintersperger,Bernd J. Wintersperger,Andrew M. Crean +8 more
TL;DR: CMR-LGE measured at 4 SD and 5 SD yields the closest approximation to the extent of total fibrosis measured by the histopathological standard of reference, which has implications for future investigations of CMR- LGE and its association with important clinical endpoints in HCM, including sudden cardiac death.
Journal ArticleDOI
Ventricular-arterial and ventricular-ventricular interactions and their relevance to diastolic filling.
TL;DR: Patients with heart failure with normal ejection fraction have been shown to have both arterial and ventricular stiffening, resulting in enhanced pressure-load dependence and sensitivity of blood pressure to circulating volume and diuretics.
Journal ArticleDOI
Toronto hypertrophic cardiomyopathy genotype score for prediction of a positive genotype in hypertrophic cardiomyopathy.
Christiane Gruner,Joan Ivanov,Melanie Care,Lynne Williams,Gil Moravsky,Hua Yang,Balint Laczay,Katherine A. Siminovitch,Anna Woo,Harry Rakowski +9 more
TL;DR: The Toronto genotype score is an accurate tool to predict a positive genotype in a hypertrophic cardiomyopathy cohort at a tertiary referral center.