http://science.sciencemag.org/content/sci/197/4303/527.full.pdf

Bioactivation as a model for drug design bioreductive alkylation

Publisher Summary This chapter presents a comprehensive list of compounds that inhibit the synthesis of adenosine triphosphate (ATP) associated with electron transport that is catalyzed by membrane systems present in mitochondria, chloroplasts, and prokaryotic cells. Inhibitors are divided into two groups. Some inhibitors interact directly with the ATPase molecule. In this group, the aurovertins, citreoviridin, Nbf-C1 (4-chloro-7-nitrobenzofurazan), quercetin, tentoxin, and efrapeptin are included. These compounds also react with and inhibit purified soluble ATPase preparations Other inhibitors react with other membrane components of the synthetase complex. These include carbodiimides, oligomycins, venturicidins, organotins, ossamycin, leucinostatin, and Dio-9. Some compounds whose inhibitory effects have not been well characterized are also discussed in the chapter. The chapter discusses the significant physical and chemical properties of these inhibitors.

[59] Inhibitors of the ATP synthetase systems☆

Structure, activity, synthesis and biosynthesis of aryl-C-glycosides

Naturally occurring quinones as potential bioreductive alkylating agents

Pyranonaphthoquinone antibiotics--isolation, structure and biological activity.

UV.-, IR.- and NMR.-spectra of the antibiotic granaticin and several of its derivatives and degradation products are discussed. The spectroscopic properties agree with the formula XX for the antibiotic, which was fully elucidated by an X-ray structural analysis (see following communication).

Stoffwechselprodukte von Mikroorganismen. 66.Mitteilung [1]. Die Struktur des Granaticins und des Granaticins B. 1. Teil: Spektroskopische Eigenschaften und chemischer Abbau

The known antibiotic Venturicidin A and two new antifungal compounds, Venturicidin B and Botrycidin, have been isolated from a strain of Streptomyces aureofaciens DUGGAR. Venturicidin B gave on methanolysis the methyl glycoside of 2-deoxy-D-rhamnose, Venturicidin A the corresponding 3-O-carbamate.

Stoffwechselprodukte von Mikroorganismen. 69. Mitteilung [1]. Über das Venturicidin B, das Botrycidin und die Zuckerbausteine der Venturicidine A und B

From a strain of Streptomyces violaceoruber, ETH 11382, a new antibiotic, granaticin B. has been isolated. Granaticin B is an L-rhodinoside of the previously described antibiotic granaticin.

M. Brufani

Papers

Stoffwechselprodukte von Mikroorganismen. 66.Mitteilung [1]. Die Struktur des Granaticins und des Granaticins B. 1. Teil: Spektroskopische Eigenschaften und chemischer Abbau

Stoffwechselprodukte von Mikroorganismen. 69. Mitteilung [1]. Über das Venturicidin B, das Botrycidin und die Zuckerbausteine der Venturicidine A und B

Stoffwechselprodukte von Mikroorganismen. Granaticin B