Reserpine: A Challenge for Total Synthesis of Natural Products

Use of rauwolfia serpentina benth. in neuropsychiatric conditions

Reserpine, C33H40O9N2, has been isolated from Rauwolfia serpentina Benth. Reserpine is an ester alkaloid yielding reserpic acid, 3,4,5-trimethoxybenzoic acid and methanol on hydrolysis. Degradation products of reserpic acid make it likely that reserpic acid is a yohimbane derivate, and a hypothetical structure for reserpine has been put forward which is in agreement with the facts known so far.

Die Konstitution des Reserpins. 8. Mitteilung über Rauwolfia-Alkaloide

The root of the Rauwolfia serpentina Benth (N. O. Apocyanaciae) has been in use in India for hundreds of years for a host of unrelated ailments. Since 1949, after the English publication of a clinical report by the author on Rauwolfia serpentina therapy in fifty cases of essential hypertension, the plant has gained universal acclamation as a useful therapeutic weapon in high blood pressure states. The whole subject of Rauwolfia serpentina therapy in hypertension has been reviewed up to the present time, including discussions on the history of the plant, its various species and types, nomenclature, geographic distribution, chemistry, pharmacologic actions and clinical studies, reported on the subject from all over the world.

Rauwolfia Serpentina in the Treatment of High Blood Pressure A Review of the Literature

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.2042-7158.1962.tb11105.x

Biological activity in steroids possessing nitrogen atoms

Alkaloids of rauwolfia serpentina benth. iii.1 rescinnamine, a new hypotensive and sedative principle

Alkaloids of Rauwolfia serpentina Benth. II.1 The Isolation of Naturally Occurring Py-tetrahydroserpentine (Ajmalicine) and a Contribution Toward its Structure

M. D. Draper

Papers

Alkaloids of rauwolfia serpentina benth. iii.1 rescinnamine, a new hypotensive and sedative principle

Alkaloids of Rauwolfia serpentina Benth. II.1 The Isolation of Naturally Occurring Py-tetrahydroserpentine (Ajmalicine) and a Contribution Toward its Structure

Alkaloids of rauwolfia serpentina benth i. the characterization of reserpine and its hydrolysis products

The Isolation of Neoprotoveratrine and Protoveratrine from Veratrum viride Ait.

The Isolation of Reserpine from Rauwolfia canescens Linn