M. De Saint Jean

TL;DR: Conjunctival cells from patients with dry eye with moderate to severe keratoconjunctivitis sicca, with or without SS, overexpress inflammatory and apoptosis-related markers, which support the use of immunomodulatory and/or anti-inflammatory drugs in the treatment of patients with KCS.

TL;DR: It is suggested that BAC induces cell growth arrest and death at a concentration as low as 0.0001%, which could in part explain some ocular surface disorders observed in patients undergoing long-term topical treatments with preservative-containing drugs.

TL;DR: Compared with an oxidative stress model of cells treated with 0.001–0.000001% hydrogen peroxide, timolol-BAC(+) induced a rapid decrease in cell viability ranging from 40% immediately after treatment to 85% 24h later and a small initial decrease in Cell viability was also observed with all tested concentrations of timolo...

TL;DR: In a model of conjunctival cells in vitro timolol-BAC(+) induced irreversible cytotoxic damage with some characteristics of apoptosis, which could explain some ocular surface disorders in long-term treated patients.

TL;DR: Investigating the effect of interferon (IFN)gamma on cell viability, cell growth, and apoptosis and on expression of apoptotic and inflammation-related proteins in epithelial conjunctival cells in vitro suggested that activation of PKC is not involved in some IFNgamma cellular effects that possibly imply the upregulation and nuclear translocation of STAT1.