Showing papers by "M. den Heijer published in 2015"
TL;DR: In this population-based study, VAT contributed beyond overall adiposity to subclinical atherosclerosis, particularly in women, which implies a specific role of VAT in the early development of Atherosclerosis.
51 citations
TL;DR: There are differences in relation between thyroid function and age between populations with differences in iodine intake in the past, despite an adequate iodine status at present, and this raises the question whether the present but also historical iodine status of a population should be taken into account when establishing the reference limits of TSH and FT4.
Abstract: Background: In populations with mild iodine deficiency, the serum level of thyrotropin (TSH) is negatively and the serum free thyroxine (FT4) is positively associated with age. An ongoing decrease of TSH and increase of FT4 can be found after iodine supplementation. The aim of this study was to investigate whether there are current differences in the relation between thyroid function and age in relation to differences in iodine intake in the past. Methods: Eight medical laboratories in several regions of The Netherlands, which are all iodine sufficient at present but with a difference in iodine status in the past, provided the results of all TSH and FT4 measurements performed from 2006 until 2011, resulting in 330,802 TSH and 103,940 FT4 measurements. Results: The negative association between TSH and age in the elderly is only present in areas with a historical iodine deficiency (regression coefficients [RC] −0.008, 95% confidence interval [CI] −0.009; −0.007). In the historically iodine-sufficient popula...
26 citations
TL;DR: This study investigates whether high‐intensity blood donation is associated with lower MetS prevalence compared with low‐ intensity blood donation, and whether iron acts as an intermediary factor.
Abstract: BACKGROUND AND OBJECTIVES: Increased iron and metabolic syndrome (MetS) go hand in hand. Frequent blood donation depletes iron stores. This study investigates whether high-intensity blood donation is associated with lower MetS prevalence compared with low-intensity blood donation, and whether iron acts as an intermediary factor. MATERIALS AND METHODS: A random sample of 422 male and 211 female active whole-blood donors >/=45 years of age was included in a cross-sectional study. Lipids, glucose and iron parameters were measured after overnight fasting. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Three groups of donation intensity were created by sex-specific tertiles of donation frequency per year and duration of donor career. RESULTS: MetS was present in 22.9% of donors. Prevalence of MetS was 1.46 (95% confidence interval [CI]: 0.93-2.30) times higher in men with high donation intensity, whereas in women MetS prevalence was 2.14 (95% CI: 0.94-4.86) times higher in donors with high donation intensity compared with those with low donation intensity. In men, increased prevalence of MetS was mainly associated with higher ferritin, whereas high hepcidin predominantly affected MetS prevalence in women. CONCLUSION: High-intensity blood donation is not associated with a decreased prevalence of MetS. In men and women, different iron parameters are associated with MetS prevalence. The temporal relationship between blood donation, iron and MetS, and gender differences herein need to be explored in future research.
13 citations