M
M.J. Chapman
Researcher at Coventry University
Publications - 22
Citations - 483
M.J. Chapman is an academic researcher from Coventry University. The author has contributed to research in topics: Identifiability & Nonlinear system. The author has an hindex of 12, co-authored 22 publications receiving 463 citations.
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Identifiability of uncontrolled nonlinear rational systems
TL;DR: An approach for the identifiability analysis of uncontrolled rational systems is provided that, provided the model satisfies an observability rank condition, the state trajectories of an uncontrolled system corresponding to parameter vectors with outputs that are identical locally in time are connected via a smooth transformation.
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The structural identifiability of the susceptible infected recovered model with seasonal forcing.
TL;DR: It is shown that the SIR epidemic model, with the force of infection subject to seasonal variation, and a proportion of either the prevalence or the incidence measured, is unidentifiable unless certain key system parameters are known, or measurable.
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A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan
Neil D. Evans,Rachel J. Errington,Mike Shelley,Graham P. Feeney,M.J. Chapman,Keith R. Godfrey,Paul Smith,Michael J. Chappell +7 more
TL;DR: A compartmental modelling approach is applied to provide a mathematical description of the activity of the anti-cancer agent topotecan, and delivery to its nuclear DNA target following administration.
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Structural identifiability for a class of non-linear compartmental systems using linear/non-linear splitting and symbolic computation.
TL;DR: Examples are presented where non-linear identifiability analyses are substantially simplified by means of an initial linear analysis for complex models with four or more compartments.
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An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine.
Neil D. Evans,Keith R. Godfrey,M.J. Chapman,Michael J. Chappell,Leon Aarons,Stephen B. Duffull +5 more
TL;DR: In this paper, the structural identifiability of a parent-metabolite pharmacokinetic model for ivabradine and one of its metabolites was investigated for both intravenous and oral administration.