The concentrations of free Mg2+ and free Zn2+ in equine blood plasma.

Reference ranges for albumin bound and alpha 2-macroglobulin bound zinc concentrations have been determined in a study of sera obtained from 134 healthy adults. The concentrations of zinc bound to alpha 2-macroglobulin were remarkably constant with a mean (+/-SD) of 2.4 +/- 0.6 mumol/l; the variations in total serum zinc concentrations were almost entirely accounted for by variations in the zinc associated with albumin. There were no sex related differences in the transport of zinc in serum; neither was this sensitive to the use of oral contraceptives. These data provide a baseline for further investigations into the effects of zinc deficiency on the serum transport of the metal.

https://jcp.bmj.com/content/jclinpath/37/9/1050.full.pdf

Albumin bound and alpha 2-macroglobulin bound zinc concentrations in the sera of healthy adults.

https://core.ac.uk/download/pdf/16664238.pdf

Allosteric modulation of zinc speciation by fatty acids.

SUMMARY Sequential changes in albumin, transferrin, a,-acid glycoprotein, Creactive protein,fibrinogen, copper, iron, and zinc in plasma up to 24 h after hysterectomy were measured. Noincreases in the concentrations of the acute phase proteins a,-acid glycoprotein, C reactiveprotein, and fibrinogen were observed until 6 h after the skin incision. These increases were precededbysignificant falls at 2-4h, andthis was shownalso byalbumin, transferrin, iron, zinc,and copper. Theratios ofiron andzinc to theirbindingproteins, transferrin andalbumin,did notdecrease until 4-6 h and their concentrations remained low for at least 24 h. These patterns suggest that at least two mechanisms operate after trauma. Theearly fall in the concentrations ofthe proteins in plasma is consistent with a prompt increase in microvascular permeability. Thelaterdecreasein bindingofthe metalsironandzinc to their transport proteinsandthe increase inconcentrations of the acute phase proteins could be initiated by a common

Early plasma protein andmineral changes after surgery:a twostage process

Sequential changes in albumin, transferrin, alpha 1-acid glycoprotein, C reactive protein, fibrinogen, copper, iron, and zinc in plasma up to 24 h after hysterectomy were measured. No increases in the concentrations of the acute phase proteins alpha 1-acid glycoprotein, C reactive protein, and fibrinogen were observed until 6 h after the skin incision. These increases were preceded by significant falls at 2-4 h, and this was shown also by albumin, transferrin, iron, zinc, and copper. The ratios of iron and zinc to their binding proteins, transferrin and albumin, did not decrease until 4-6 h and their concentrations remained low for at least 24 h. These patterns suggest that at least two mechanisms operate after trauma. The early fall in the concentrations of the proteins in plasma is consistent with a prompt increase in microvascular permeability. The later decrease in binding of the metals iron and zinc to their transport proteins and the increase in concentrations of the acute phase proteins could be initiated by a common mediator.

https://jcp.bmj.com/content/jclinpath/37/8/862.full.pdf

Early plasma protein and mineral changes after surgery: a two stage process.

Determination of native zinc content of alpha-2-macroglobulin in normal, hyperzincemic and hypozincemic sera by sucrose density gradient centrifugation.

M.K. Song

Papers

Determination of native zinc content of alpha-2-macroglobulin in normal, hyperzincemic and hypozincemic sera by sucrose density gradient centrifugation.