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A review on versatile applications of transition metal complexes incorporating Schiff bases

, which are condensation products ofprimary amines and aldehydes or ketones (RCH=NR ′,where R & R ′ represents alkyl and / or aryl substituents).This paper reviews uses of Schif f bases and their metalcomplexes as catalysts, in various biological systems,polymers and dyes, besides some uses as antifertilityand enzymatic agents.

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Applications of metal complexes of Schiff bases-A review

https://recipp.ipp.pt/bitstream/10400.22/7411/1/ART_AnaPessoa_2015_2.pdf

Quinoxaline, its derivatives and applications: A state of the art review.

Principles of bioinorganic chemistry

In recent years, the number of people suffering from cancer and multidrug-resistant infections has sharply increased, leaving humanity without any choice but to search for new treatment options and strategies. Although cancer is considered the leading cause of death worldwide, it also paves the way many microbial infections and thus increases this burden manifold. Development of small molecules as anticancer and anti-microbial agents has great potential and a plethora of drugs are already available to combat these diseases. However, the wide occurrence of multidrug resistance in both cancer and microbial infections necessitates the development of new and potential molecules with desired properties that could circumvent the multidrug resistance problem. A successful strategy in anticancer chemotherapy has been the use of metallo-drugs and this strategy has the potential to be used for treating multidrug-resistant infections more efficiently. As a class of molecules, Schiff bases have been the topic of considerable interest, owing to their versatile metal chelating properties, inherent biological activities and flexibility to modify the structure to fine-tune it for a particular biological application. Schiff base-based metallo-drugs are being researched to develop new anticancer and anti-microbial chemotherapies and because both anticancer and anti-microbial targets are different, heterocyclic Schiff bases can be structurally modified to achieve the desired molecule, targeting a particular disease. In this review, we collect the most recent and relevant literature concerning the synthesis of heterocyclic Schiff base metal complexes as anticancer and anti-microbial agents and discuss the potential and future of this class of metallo-drugs as either anticancer or anti-microbial agents.

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Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy.

Synthesis, characterization and biological activity of some transition metals with Schiff base derived from 2-thiophene carboxaldehyde and aminobenzoic acid.

Metal complexes of Schiff bases derived from 2-furancarboxaldehyde and o-phenylenediamine (L1), and 2-thiophenecarboxaldehyde and 2-aminothiophenol (HL2) are reported and characterized based on elemental analyses, IR 1H NMR, solid reflectance, magnetic moment, molar conductance, and thermal analysis (TGA). The ligand dissociation, as well as the metal-ligand stability constants were calculated, pH-metrically, at 25 °C and ionic strength m = 0.1 (1 M NaCl). The complexes are found to have the formulae [M(L1)(H2O)2](Cl)n \cdot yH2O (where M = Fe(III), Ni(II), Cu(II); n = 2-3, y = 2-4); [M(L1)](X)2 \cdot yH2O (where M = Co(II), Zn(II), UO2(II), X = Cl, AcO or NO3, y = 1-3); [M(L2)2] \cdot yH2O (where M = Co(II), Ni(II), Cu(II); X = Cl; y = 0-2 and Zn(II); X = AcO, y = 0); and [Fe(L2)2]Cl \cdot 2H2O and [UO2(HL2)2](NO3)2. The molar conductance data reveal that all the metal chelates of the L1 ligand, and Fe(III) and UO2(II) chelates of HL2 are electrolytes, while Co(II), Ni(II), Cu(II), and Zn(II) chelates of HL2 are non-electrolytes. IR spectra show that L1 is coordinated to the metal ions in a tetradentate manner, with ONNO donor sites of azomethine--N and furan-O, whereas the HL2 ligand is coordinated to the metal ions in a terdentate manner with SNS donor sites of azomethine--N, thiophene-S, and thiol-S. From the magnetic and solid reflectance spectra, it is found that the geometrical structures of these complexes are octahedral and tetrahedral. The thermal behavior of these chelates shows that the hydrated complexes lose water molecules of hydration in the first step and is immediately followed by decomposition of the anions and ligand molecules in the subsequent steps. The activation thermodynamic parameters, such as E*, D H*, D S*, and D G*, are calculated from the DrTG curves using the Coats-Redfern method. The synthesized ligands, in comparison to their metal complexes, were also screened for their antibacterial activity against bacterial species, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus Pyogones, as well as fungi (Candida). The activity data show the metal complexes to be more potent antibacterials than the parent Schiff base ligand against one or more bacterial species.

/pdf/metal-complexes-of-schiff-bases-preparation-characterization-2reyxu5ns3.pdf

M.M. Omar

Papers

Synthesis, characterization and biological activity of some transition metals with Schiff base derived from 2-thiophene carboxaldehyde and aminobenzoic acid.

Metal Complexes of Schiff Bases: Preparation, Characterization, and Biological Activity

Biological activity studies on metal complexes of novel tridentate Schiff base ligand. Spectroscopic and thermal characterization.

Potentiometric, spectroscopic and thermal studies on the metal chelates of 1-(2-thiazolylazo)-2-naphthalenol.

Spectroscopic characterization of metal complexes of novel Schiff base. Synthesis, thermal and biological activity studies.