Strategies in optical resolutions

Racemic thalidomide is chromatographically separated on optically active polyamide giving both enantiomers After ip administration only the S-(-)-enantiomer is teratogenic on SWS mice and Natal rats

Chromatographische Racemattrennung von Thalidomid und teratogene Wirkung der Enantiomere

The synthetic utility of oxyallyl cations

A number of racemates can be resolved into optically pure enantiomers by chromatography on optically active adsorbents. Synthetic polymers with optically active amide, amino acid, and crown ether groups, natural products such as starch and cellulose, and also microcrystalline triacetylcellulose are suitable for this purpose. Racemates can also be resolved by gas chromatography on optically active stationary phases.

M. S. Hoekstra

Papers

Automated liquid chromatography. Synthesis of a broad-spectrum resolving agent and resolution of 1-(1-naphthyl)-2,2,2-trifluoroethanol