M. S. Zharkova

TL;DR: Examination of a combined action of natural AMPs with different structure and mode of action with varied antibiotic agents found that synergy in antibacterial action mainly occurs between highly membrane-active AMPs and antibiotics with intracellular targets, suggesting bioavailability increase as the main model of such interaction.

TL;DR: In this article, the authors investigated the direct redox activity of different proteins on the surface of carbon screen printed electrodes (SPE), and the signal attributed to the electrochemical oxidation of amino acid residues (cysteine (Cys), tryptophan (Trp) and tyrosine (Tyr)) was registered at Emax from 0.6 to 0.7

TL;DR: Electrochemical data indicate that oxazolinyl derivative of [17(20)E]-pregna-5, 17(20)-diene 1 (rather than 4',4'-dimethyl derivative 2) may be considered as potential CYP17A1 inhibitor and template for development of new compounds affecting growth and proliferation of prostate cancer cells.

TL;DR: The results indicate that the arenicin scaffold can support a considerable degree of variation while maintaining useful biological properties and can thus serve as a template for the elaboration of novel anti-infective agents.

TL;DR: Isolation of highly active fragments of the antimicrobial peptide from goat neutrophils supports the hypothesis that fragmentation of cathelicidin-related AMPs is an important process that results in the generation of potent effector molecules, which are in some cases more active than full-size AMPs.