M
M Seto
Researcher at Washington University in St. Louis
Publications - 3
Citations - 1005
M Seto is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Chromosomal translocation & Promoter. The author has an hindex of 3, co-authored 3 publications receiving 999 citations.
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Journal ArticleDOI
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.
TL;DR: The most common translocation in human lymphoma, the t(14;18)(q32;q21), generates heterogeneous 4.2‐7.2 kb Bcl‐2‐immunoglobulin (Ig) chimeric mRNAs resulting from alternative B cl‐2 5′ exons and varied Ig 3′ untranslated regions (UT).
Journal ArticleDOI
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.
TL;DR: There is a marked deregulation of Bcl-2 when it is introduced into the Ig locus in t(14;18) lymphomas, which has implications for hematopoietic lineages including T cells.
Journal ArticleDOI
Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.
Ajay Bakhshi,J J Wright,W. Graninger,M Seto,J Owens,Jeffrey Cossman,Jane P. Jensen,P Goldman,Stanley J. Korsmeyer +8 more
TL;DR: The results prompt a translocation model with illegitimate pairing of a staggered double-stranded DNA break at 18q21 and an immunoglobulin endonuclease-mediated break at 14q32 and with N-segment addition, repair, and ligation to generate der(14) and der(18) chromosomes.