M
M. Teresa Grande
Researcher at University of Salamanca
Publications - 2
Citations - 630
M. Teresa Grande is an academic researcher from University of Salamanca. The author has contributed to research in topics: Renal fibrosis & Knockout mouse. The author has an hindex of 2, co-authored 2 publications receiving 499 citations. Previous affiliations of M. Teresa Grande include Universidad Miguel Hernández de Elche.
Papers
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Journal ArticleDOI
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease
M. Teresa Grande,Berta Sanchez-Laorden,Cristina López-Blau,Cristina A. de Frutos,Agnès Boutet,Miguel Arévalo,R. Grant Rowe,Stephen J. Weiss,José M. López-Novoa,M. Angela Nieto +9 more
TL;DR: It is shown that the reactivation of Snai1 in mouse renal epithelial cells is required for the development of fibrosis in the kidney and that Snail1-induced fibrosis can be reversed in vivo and that obstructive nephropathy can be therapeutically ameliorated in mice by targeting Snails1 expression.
Journal ArticleDOI
Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice.
M. Teresa Grande,Isabel Fuentes-Calvo,Miguel Arévalo,Fabiana Heredia,Eugenio Santos,Carlos Martínez-Salgado,Diego Rodríguez-Puyol,M. Angela Nieto,José M. López-Novoa +8 more
TL;DR: As expected, lower levels of activated Akt in the kidneys and cultured fibroblasts of the knockout were found, and Interestingly, fibronectin, collagen I accumulation, overall interstitial fibrosis, and the myofibroblast population were also lower in the knockout than in the wild-type mice.