M
M. Vandewalle
Researcher at Ghent University
Publications - 133
Citations - 1286
M. Vandewalle is an academic researcher from Ghent University. The author has contributed to research in topics: Total synthesis & Mass spectrometry. The author has an hindex of 18, co-authored 133 publications receiving 1272 citations.
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Journal ArticleDOI
Photoinduced Wolff Rearrangement of α-Diazo-β-Ketophosphonates : A Novel Entry into Substituted Phosphonoacetates
TL;DR: In this article, the functionalized isopropyl group present in many sesquiterpenes was constructed using direct irradiation of α-diazo-β-ketophosphona-tes in the presence of an alcohol, leading to substituted phosphonoacetates.
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Enantioselective total synthesis of (−)-epipodophyllotoxin and (−)-podophyllotoxin
TL;DR: In this article, an enantioselective total synthesis of (−)-epipodophyllotoxin (2) and hence of (1) was described, involving as key steps a conjugate addition on butenolide 13 as the chiral template.
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Biologic activity of dihydroxylated 19-nor-(pre)vitamin D3.
Roger Bouillon,Luis A. Sarandeses,K Allewaert,Jie Zhao,José L. Mascareñas,Antonio Mouriño,S. Vrielynck,P. De Clercq,M. Vandewalle +8 more
TL;DR: It is concluded that the previtamin D form of 1α,25‐(OH)2‐19‐nor‐D3 has lost most of its biologic activity in vitro and in vivo.
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Iridoids: stereospecific synthesis of functionalized cyclopentanoid intermediates via bicyclo [2.2.1] heptanones
TL;DR: In this paper, an efficient synthesis of functionalized trialkyl substituted cyclopentanoids is presented, secured by their formation from norbornane precusors, which is illustrated by the total synthesis of (±)-boschnialactone (13 ), (±-teucriumlactone C ( 14 ) and (±]-loganin ( 2 ).
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The synthesis of 2-azapodophyllotoxins
TL;DR: In this paper, tetrahydroisoquinoline analogues of podophyllotoxin have been synthesized, which constitute a new class of highly potent anti-tumor agents.