M
Maciej Ciesla
Researcher at Jagiellonian University
Publications - 25
Citations - 946
Maciej Ciesla is an academic researcher from Jagiellonian University. The author has contributed to research in topics: Heme oxygenase & Biology. The author has an hindex of 12, co-authored 18 publications receiving 803 citations. Previous affiliations of Maciej Ciesla include Lund University.
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Journal ArticleDOI
Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease
Philip Michael Gaughwin,Maciej Ciesla,Maciej Ciesla,Nayana Lahiri,Sarah J. Tabrizi,Patrik Brundin,Maria Björkqvist +6 more
TL;DR: This is the first study suggesting that plasma miRs might be used as biomarkers for HD, and it is found that miR-34b is significantly elevated in response to mHTt-Exon-1, and its blockade alters the toxicity of mHTT-ExOn-1 in vitro.
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Stage-Specific Modulation of Cortical Neuronal Development by Mmu-miR-134
Philip Michael Gaughwin,Philip Michael Gaughwin,Maciej Ciesla,Henry Yang,Bing Lim,Bing Lim,Patrik Brundin +6 more
TL;DR: Dcx and Chrdl-1 are presented as new regulatory targets of miR-134 during embryonic, mouse, cortical, and neuronal differentiation and show a novel and previously undiscovered role for miR -134 in the stage-specific modulation of cortical development.
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Interplay Between Heme Oxygenase-1 and miR-378 Affects Non-Small Cell Lung Carcinoma Growth, Vascularization, and Metastasis
Klaudia Skrzypek,Magdalena Tertil,Slawomir Golda,Maciej Ciesla,Kazimierz Weglarczyk,Guillaume Collet,Alan Guichard,Magdalena Kozakowska,Jorge Boczkowski,Halina Was,Tomasz Gil,Jarosław Kużdżał,Lucie Muchová,Libor Vítek,Agnieszka Loboda,Alicja Jozkowicz,Claudine Kieda,Jozef Dulak +17 more
TL;DR: In vitro and in vivo data indicate that the interplay between HMOX1 and miR-378 significantly modulates NSCLC progression and angiogenesis, suggesting miR -378 as a new therapeutic target.
Journal ArticleDOI
Heme Oxygenase-1 Inhibits Myoblast Differentiation by Targeting Myomirs
Magdalena Kozakowska,Maciej Ciesla,Anna Stefanska,Klaudia Skrzypek,Halina Was,Agnieszka Jazwa,Anna Grochot-Przeczek,Jerzy Kotlinowski,Agnieszka Szymula,Aleksandra Bartelik,Milena Mazan,Oleksandr Yagensky,Urszula Florczyk,Krzysztof Lemke,Anna Zebzda,Grzegorz Dyduch,Witold Nowak,Krzysztof Szade,Jacek Stępniewski,Marcin Majka,Rafal Derlacz,Agnieszka Loboda,Jozef Dulak,Alicja Jozkowicz +23 more
TL;DR: HMOX1 improves the survival of myoblasts, but concurrently through regulation of myomirs, may act similarly to oncogenes, increasing the risk of hyperplastic growth of myogenic precursors.
Journal ArticleDOI
MicroRNAs as biomarkers of disease onset
Maciej Ciesla,Klaudia Skrzypek,Magdalena Kozakowska,Agnieszka Loboda,Alicja Jozkowicz,Jozef Dulak +5 more
TL;DR: Small, noncoding RNA molecules with the ability to posttranscriptionally regulate gene expression via targeting the 3′ untranslated region of messenger RNAs are critical for normal cellular functions such as the regulation of the cell cycle, differentiation, and apoptosis.