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Madeline J. Simpson
Researcher at McMaster University
Publications - 8
Citations - 244
Madeline J. Simpson is an academic researcher from McMaster University. The author has contributed to research in topics: Silver nanoparticle & Silver nitrate. The author has an hindex of 6, co-authored 8 publications receiving 193 citations. Previous affiliations of Madeline J. Simpson include University of Ottawa.
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Journal ArticleDOI
Safety and efficacy of composite collagen–silver nanoparticle hydrogels as tissue engineering scaffolds
Emilio I. Alarcon,Klas I. Udekwu,Christopher W. Noel,Luke B.-P. Gagnon,Patrick K. Taylor,Branka Vulesevic,Madeline J. Simpson,Spyridon Gkotzis,Mohammed Mirazul Islam,Mohammed Mirazul Islam,Chyan-Jang Lee,Agneta Richter-Dahlfors,Thien-Fah Mah,Erik J. Suuronen,Juan C. Scaiano,Juan C. Scaiano,May Griffith,May Griffith +17 more
TL;DR: The safety and efficacy of the incorporation of collagen coated AgNPs into collagen hydrogels for tissue engineering and an analysis of silver contents in implanted mice showed that silver accumulation primarily occurred within the tissue surrounding the implant.
Journal ArticleDOI
LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control
Mariana Vignoni,Hasitha de Alwis Weerasekera,Madeline J. Simpson,Jaywant Phopase,Thien-Fah Mah,May Griffith,Emilio I. Alarcon,Juan C. Scaiano,Juan C. Scaiano +8 more
TL;DR: Capping silver nanoparticles with LL37 peptide eradicates the antiproliferative effect of silver on primary skin cells, but retains the bactericidal properties of silver nanoparticle with activities comparable to silver nitrate or silver sulfadiazine.
Journal ArticleDOI
Intranasal delivery of antipsychotic drugs.
Yogesh K. Katare,Justin E. Piazza,Jayant Bhandari,Ritesh Daya,Kosalan Akilan,Madeline J. Simpson,Todd Hoare,Ram K. Mishra +7 more
TL;DR: If limitations of low aqueous solubility of antipsychotic drugs can be overcome and non-toxic formulations used, IN delivery will gain more importance moving forward given the inherent benefits of IN delivery in comparison to other methods.
Journal ArticleDOI
Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents
Madeline J. Simpson,Daisy Hjelmqvist,Camilo López-Alarcón,Nadja Karamehmedovic,Thomas G. Minehan,Akop Yepremyan,Baback Salehani,Eduardo Lissi,Elizabeth Joubert,Klas I. Udekwu,Emilio I. Alarcon +10 more
TL;DR: The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated and it was observed that the artificial infusions showed greater antioxidant quality than the latter infusions, reaching values close to those reported for tea infusions.
Journal ArticleDOI
Impact of Dye-Protein Interaction and Silver Nanoparticles on Rose Bengal Photophysical Behavior and Protein Photocrosslinking †
Madeline J. Simpson,Horacio Poblete,May Griffith,May Griffith,Emilio I. Alarcon,Juan C. Scaiano,Juan C. Scaiano +6 more
TL;DR: The presence of Ag NP in the form of AgNP@collagen altered the dynamics of dye triplet deactivation, effectively preventing the dye degradation and reducing the extent of protein crosslinked.