M
Madhukar S. Dasika
Publications - 1
Citations - 447
Madhukar S. Dasika is an academic researcher. The author has contributed to research in topics: Metabolic engineering. The author has an hindex of 1, co-authored 1 publications receiving 314 citations.
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Rewriting yeast central carbon metabolism for industrial isoprenoid production
Adam L. Meadows,Kristy Michelle Hawkins,Yoseph Tsegaye,Eugene Antipov,Youngnyun Kim,Lauren Raetz,Robert H. Dahl,Anna Tai,Tina Mahatdejkul-Meadows,Lan Xu,Lishan Zhao,Madhukar S. Dasika,Abhishek Murarka,Jacob R. Lenihan,Diana Eng,Joshua S. Leng,Chi-Li Liu,Jared W. Wenger,Hanxiao Jiang,Lily Chao,Patrick J. Westfall,Jefferson Lai,Savita Ganesan,Peter K. Jackson,Robert Mans,Darren Platt,Christopher D. Reeves,Poonam R. Saija,Gale Wichmann,Victor F. Holmes,Kirsten R. Benjamin,Paul W. Hill,Timothy S. Gardner,Annie Ening Tsong +33 more
TL;DR: Four non-native metabolic reactions are used to rewire central carbon metabolism in S. cerevisiae, enabling biosynthesis of cytosolic acetyl coenzyme A (acetyl-CoA, the two-carbon isoprenoid precursor) with a reduced ATP requirement, reduced loss of carbon to CO2-emitting reactions, and improved pathway redox balance.